Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri. (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1474-9726.2009.00455.x (literal)

Alternative label

• Eva Terzibasi, 1 Christel Lefrançois, 3,4 Paolo Domenici, 4 Nils Hartmann, 2 Michael Graf 2 and Alessandro Cellerino 1,5 (2009)
  Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri.
  in Aging cell (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Eva Terzibasi, 1 Christel Lefrançois, 3,4 Paolo Domenici, 4 Nils Hartmann, 2 Michael Graf 2 and Alessandro Cellerino 1,5 (literal)

Pagina inizio

• 88 (literal)

Pagina fine

• 99 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2009.00455.x/abstract;jsessionid=C6B9C4D2686E7F1773999EE27598B583.d01t03 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 8 (literal)

Rivista

• Aging cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Biology of Aging and 2 Molecular Genetics, Fritz Lipmann Institute for Age Research, Leibniz Institute, Jena 07745 Germany 3 Littoral Environnement et Sociétés-Centre national de la recherche scientifique, Unité Mixte de Recherche 6250, University of La Rochelle, France 4 CNR- IAMC, Oristano Italy (literal)

Titolo

• Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri. (literal)

Abstract

• The short-lived annual fish Nothobranchius furzeri shows extremely short captive life span and accelerated expression of age markers, making it an interesting model system to investigate the effects of experimental manipulations on longevity and age-related pathologies. Here, we tested the effects of dietary restriction (DR) on mortality and age-related markers in N. furzeri. DR was induced by every other day feeding and the treatment was performed both in an inbred laboratory line and a longer-lived wild-derived line. In the inbred laboratory line, DR reduced age-related risk and prolonged maximum life span. In the wild-derived line, DR induced early mortality, did not reduce general age-related risk and caused a small but significant extension of maximum life span. Analysis of age-dependent mortality revealed that DR reduced demographic rate of aging, but increased baseline mortality in the wild-derived strain. In both inbred- and wild-derived lines, DR prevented the expression of the age markers lipofuscin in the liver and Fluoro-Jade B (neurodegeneration) in the brain. DR also improved performance in a learning test based on conditioning (active avoidance in a shuttle box). Finally, DR induced a paradoxical up-regulation of glial fibrillary acidic protein in the brain. (literal)

Prodotto di

• Sviluppo di tecnologie e metodologie per l'acquisizione e l'interpretazione e la diffusione di dati di geologia marina e ambientale per la gestione sostenibile (TA.P07.016.001) (Modulo)
• Institute for coastal marine environment (IAMC) (Istituto)

Autore CNR

• PAOLO DOMENICI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute for coastal marine environment (IAMC) (Istituto)
• Sviluppo di tecnologie e metodologie per l'acquisizione e l'interpretazione e la diffusione di dati di geologia marina e ambientale per la gestione sostenibile (TA.P07.016.001) (Modulo)

Autore CNR di

• PAOLO DOMENICI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Aging cell (Rivista)

Insieme di parole chiave di

• Keywords of "Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri." (Insieme di parole chiave)