http://www.cnr.it/ontology/cnr/individuo/prodotto/ID62881

Fibrin resistance to lysis in patients with pulmonary hypertension other than thromboembolic (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Fibrin resistance to lysis in patients with pulmonary hypertension other than thromboembolic (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1164/rccm.200907-1135OC (literal)

Alternative label

Miniati M.; Fiorillo C.; Becatti M.; Monti S.; Bottai M.; Marini C.; Grifoni E.; Formichi B.; Bauleo C.; Arcangeli C.; Poli D.; Nassi P.; Abbate R.; Prisco D. (2010)
Fibrin resistance to lysis in patients with pulmonary hypertension other than thromboembolic
in American journal of respiratory and critical care medicine; American Thoracic Society, New York (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Miniati M.; Fiorillo C.; Becatti M.; Monti S.; Bottai M.; Marini C.; Grifoni E.; Formichi B.; Bauleo C.; Arcangeli C.; Poli D.; Nassi P.; Abbate R.; Prisco D. (literal)

Pagina inizio

992 (literal)

Pagina fine

996 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://ajrccm.atsjournals.org/ (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

181 (literal)

Rivista

American journal of respiratory and critical care medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

In: American Journal of Respiratory and Clinical Care Medicine, vol. 181 pp. 992 - 996. Stanford University Libraries' HighWire Press®, 2010. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

5 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Univ Florence, Dipartimento Area Crit Med Chirug, I-50134 Florence, Italy; Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy; Azienda Osped Univ Careggi, Struttura Operat Dipartimentale Malattie Aterotro, Florence, Italy; Azienda Osped Univ Careggi, Dipartimento Cuore & Vasi, Florence, Italy; CNR, Ist Fisiol Clin, Pisa, Italy; Univ S Carolina, Arnold Sch Publ Hlth, Columbia, SC 29208 USA (literal)

Titolo

Fibrin resistance to lysis in patients with pulmonary hypertension other than thromboembolic (literal)

Abstract

Rationale: Reportedly, fibrin isolated from patients with chronic thromboembolic pulmonary hypertension (CTEPH) is resistant to lysis. Persistence of regions within the fibrin beta chain, which mediate cell signaling and migration, could trigger the organization of pulmonary thromboemboli into chronic intravascular scars. Objectives: Ascertain whether fibrin resistance to lysis occurs in patients with pulmonary hypertension (PAH) other than CTEPH, and in those with prior pulmonary embolism (PE) and no pulmonary hypertension. Methods: Fibrinogen was purified from 96 subjects (17 with CTEPH, 14 with PAH, 39 with prior PE, and 26 healthy control subjects) and exposed to thrombin to obtain fibrin clots. Plasmin-mediated cleavage of fibrin 13 chain was assessed hourly over a 6-hour period by polyacrylamide gel electrophoresis. Fibrin band intensity was measured by densitometry of stained gels. Data were normalized to the band intensity of the undigested protein. Measurements and Main Results: By 1 hour of digestion, fibrin band intensity had decreased by a median of 25% (interquartile range [IQR], 20 to 27%) in control subjects, and by 15% (IQR, 11 to 18%) in patients with prior PE (P < 0.0001). The 1-hour median reduction in band intensity was 2% (IQR, 1 to 3%) in CTEPH, and 4% (IQR, 2 to 7%) in PAH (P < 0.0001 vs. control subjects and PE). The decline in fibrin band intensity remained significantly different among the four groups up to 6 hours (P < 0.0001). Conclusions: Fibrin resistance to lysis occurs in pulmonary hypertension other than CTEPH and, to a smaller extent, in patients with prior PE and no pulmonary hypertension. (literal)

Editore