Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type 2 diabetes (Articolo in rivista)

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Label
  • Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type 2 diabetes (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Gastaldelli A.; Casolaro A.; Pettiti M.; Nannipieri M.; Ciociaro D.; Frascerra S.; Buzzigoli E.; Baldi S.; Mari A.; Ferrannini E. (2007)
    Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type 2 diabetes
    in Clinical pharmacology and therapeutics
    (literal)
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  • Gastaldelli A.; Casolaro A.; Pettiti M.; Nannipieri M.; Ciociaro D.; Frascerra S.; Buzzigoli E.; Baldi S.; Mari A.; Ferrannini E. (literal)
Pagina inizio
  • 205 (literal)
Pagina fine
  • 212 (literal)
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  • http://www.ncbi.nlm.nih.gov/pubmed/17259945 (literal)
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  • 81 (literal)
Rivista
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  • In: Clinical Pharmacology & Therapeutics, vol. 81 pp. 205 - 212. Clin Pharmacol Ther, 2007. (literal)
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  • [1,3,5,7] CNR Inst Clin Physiol [2,4,6,8,10]Univ Pisa, Sch Med, Dept Internal Med, I-56100 Pisa, Italy [9]CNR, Inst Biomed Engn, Padua, Italy (literal)
Titolo
  • Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type 2 diabetes (literal)
Abstract
  • We explored the mechanisms by which a 4-month, placebo-controlled pioglitazone treatment (45 mg/day) improves glycemic control in type II diabetic patients (T2D, n=27) using physiological testing (6-h mixed meal) and a triple tracer technique ([6,6-(2)H(2)]glucose infusion, (2)H(2)O and [6-(3)H]glucose ingestion) to measure endogenous glucose production (EGP), gluconeogenesis (GNG), insulin-mediated glucose clearance and beta-cell glucose sensitivity (by c-peptide modeling). Compared to sex/age/weight-matched non-diabetic controls, T2D patients showed inappropriately (for prevailing insulinemia) raised glucose production (1.05[0.53] vs 0.71[0.36]mmol min(-1) kg(ffm)(-1) pM, P=0.03) because of enhanced GNG (73.1+/-2.4 vs 59.5+/-3.6%, P0.01) persisting throughout the meal, reduced insulin-mediated glucose clearance (6[5] vs 12[13]ml min(-1) kg(ffm)(-1) nM(-1), P0.005), and impaired beta-cell glucose-sensitivity (27[38] vs 71[37]pmol min(-1) m(-2) mM(-1), P (literal)
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