Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of the M2 receptor subtype. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of the M2 receptor subtype. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Loreti S, Ricordy R, Egle De Stefano M, Augusti-Tocco G, Maria Tata A. (2007)
  Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of the M2 receptor subtype.
  in Neuron glia biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Loreti S, Ricordy R, Egle De Stefano M, Augusti-Tocco G, Maria Tata A. (literal)

Pagina inizio

• 269 (literal)

Pagina fine

• 279 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3 (literal)

Rivista

• Neuron glia biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Inst Biol & Mol Pathol, Rome, Italy (literal)

Titolo

• Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of the M2 receptor subtype. (literal)

Abstract

• Cultures of schwalla cells froill ncoaatal rat sciatic aenes ivere treated with acety1cholilic agonists tvid the cjj cts oil cell Prolificratiou cniluatcd. 3[HI-thyaiidiac incorporation shows that accty1choliac (ACh) receptor agoiiists ilillibit cell proliftratioti, aiid FACS analysis deinoustratcs ccll-cyclc arrest and accunlulatioii of cells ill the Gi phase. The use of arecaiditie, a selective agouist of niuscariiiic M2 receptors reveals that this effect depends nictitily oil jW2 receptor acth,atioii. The arecaidine i1cpetialci i t- block ill Gi is rci,ersible becausc reinoval of arecaidiue froai the culture iiieditaii mduccs progrcssioil to the S phase. The block of the Gj-S transitioil is also characterized by inodulatiou of the expressioti ofscwrol cell-cycic inarkcrs. Morcoi,cr, trcatnicat ivith ACh receptor agmist causes both a decreasc ill the PCNA prolcin lci,cls ill Schivaiiii cell iniclci aad all iiicreasc ill P27 Olld P53 proteins. Filially, iinnnuio-elcctrou inicroscopy dcalonStl-atCS that M2 receptors arc expressed by Schivanii cells ill i,ivo. These results inclicate that ACh, by aiodulatiiig Schwaiin cell prolificratioii through M2 I-CCCPtOl- aclivatioa,)iiight cowributc to their progression to a niore dif rewiated phenotype. (literal)

Prodotto di

• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)
• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• RUGGERO RICORDY (Unità di personale interno)

Incoming links:

Autore CNR di

• RUGGERO RICORDY (Unità di personale interno)

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuron glia biology (Rivista)