Different transcriptional profile of human monocyte-derived dendritic cells infected with distinct strains of mycobacterium tuberculosis and mycobacterium bovis bacillus Calmette-Guérin (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Different transcriptional profile of human monocyte-derived dendritic cells infected with distinct strains of mycobacterium tuberculosis and mycobacterium bovis bacillus Calmette-Guérin (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Sanarico N.1,2. Colone A.1,3, Grassi M.1, Speranza V.1, Giovannini D.1,3, Ciaramella A.4, Colizzi V.3, Mariani F.1 (2011)
  Different transcriptional profile of human monocyte-derived dendritic cells infected with distinct strains of mycobacterium tuberculosis and mycobacterium bovis bacillus Calmette-Guérin
  in Clinical & developmental immunology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sanarico N.1,2. Colone A.1,3, Grassi M.1, Speranza V.1, Giovannini D.1,3, Ciaramella A.4, Colizzi V.3, Mariani F.1 (literal)

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• Article ID 741051, 14 pages - doi:10.1155/2011/741051 (literal)

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• 2011 (literal)

Rivista

• Clinical & developmental immunology (Rivista)

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• Invited submission on October 2010 to Special Issue of Clinical Developmental Immunology: TB Immunology, accepted on 13 January 2011. (literal)

Note

• ISI Web of Science (WOS) (literal)

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• 1 - Institute of Cell Biology and Neurobiology, National Research Council, Via del Fosso del Cavaliere, 100, 00133 Rome, Italy. 2 - National AIDS Centre, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. 3 - Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy. 4 - Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy. (literal)

Titolo

• Different transcriptional profile of human monocyte-derived dendritic cells infected with distinct strains of mycobacterium tuberculosis and mycobacterium bovis bacillus Calmette-Guérin (literal)

Abstract

• In order to analyze dendritic cells (DCs) activation following infection with different mycobacterial strains, we studied the expression profiles of 165 genes of human monocyte-derived DCs infected with H37Rv, a virulent Mycobacterium tuberculosis (MTB) laboratory strain, CMT97, a clinical MTB isolate, Mycobacterium bovis bacillus Calmette-Guérin (BCG), Aventis Pasteur, and BCG Japan, both employed as vaccine against tuberculosis. The analysis of the gene expression reveals that, despite a set of genes similarly modulated, DCs response resulted strain dependent. In particular, H37Rv significantly upregulated EBI3 expression compared with BCG Japan, while it was the only strain that failed to release a significant IL-10 amount. Of note, BCG Japan showed a marked increase in CCR7 and TNF-± expression regarding both MTB strains and it resulted the only strain failing in exponential intracellular growth. Our results suggest that DCs display the ability to elicit a tailored strain-specific immune response. (literal)

Prodotto di

• ex ME.P03.007.001 / Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.002) (Modulo)

Autore CNR

• FRANCESCA MARIANI (Persona)

Incoming links:

Autore CNR di

• FRANCESCA MARIANI (Persona)

Prodotto

• ex ME.P03.007.001 / Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Clinical & developmental immunology (Rivista)