Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats (Articolo in rivista)

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  • Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s00726-010-0818-6 (literal)
Alternative label
  • Sibilia Valeria1; Pagani Francesca1; Bulgarelli Ilaria1;Tulipano Giovanni2; Possenti Roberta3,4; Guidobono Francesca1 (2012)
    Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats
    in Amino acids (Wien, Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sibilia Valeria1; Pagani Francesca1; Bulgarelli Ilaria1;Tulipano Giovanni2; Possenti Roberta3,4; Guidobono Francesca1 (literal)
Pagina inizio
  • 1261 (literal)
Pagina fine
  • 1268 (literal)
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  • 42 (literal)
Rivista
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  • 7 (literal)
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  • 4 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Department of Pharmacology, Chemotherapy and Medical Toxicology, Universit√† degli Studi di Milano, Via Vanvitelli, 32, 20129 Milan, Italy. 2 Division of Pharmacology and Toxicology, Department of Biomedical Sciences and Biotechnology, Universit√† degli Studi di Brescia, Brescia, Italy. 3 Institute of Neurobiology and Molecular Medicine, CNR, Via del Fosso di Fiorano 64/65, Rome, Italy. 4 Department of Neuroscience, University \"Tor Vergata\", Rome, Italy (literal)
Titolo
  • Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats (literal)
Abstract
  • TLQP-21, a vgf-derived peptide modulates gastric emptying and prevents ethanol-induced gastric lesions in rats. However, it remains to be studied whether or not TLQP-21 affects gastric acid secretion. In this study, we evaluated the effects of central (0.8-8 nmol/rat) or peripheral (48-240 nmol/kg, intraperitoneally) TLQP-21 administration on gastric acid secretion in pylorus-ligated rats. The mechanisms involved in such activity were also examined. Central TLQP-21 injection significantly reduced gastric acid volume and dose-dependently inhibited total acid output (ED(50) = 2.71 nmol), while peripheral TLQP-21 administration had no effect. The TLQP-21 antisecretory activity was prevented by cysteamine (300 mg/kg, subcutaneously), a depletor of somatostatin, by indomethacin (0.25 mg/rat, intracerebroventricularly), a non-selective cyclooxygenase inhibitor, and by functional ablation of sensory nerves by capsaicin. We conclude that TLQP-21 could be considered a new member of the large group of regulatory peptides affecting gastric acid secretion. The central inhibitory effect of TLQP-21 on gastric acid secretion is mediated by endogenous somatostatin and prostaglandins and requires the integrity of sensory nerve fibres. (literal)
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