Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00726-010-0818-6 (literal)

Alternative label

• Sibilia Valeria1; Pagani Francesca1; Bulgarelli Ilaria1;Tulipano Giovanni2; Possenti Roberta3,4; Guidobono Francesca1 (2012)
  Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats
  in Amino acids (Wien, Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sibilia Valeria1; Pagani Francesca1; Bulgarelli Ilaria1;Tulipano Giovanni2; Possenti Roberta3,4; Guidobono Francesca1 (literal)

Pagina inizio

• 1261 (literal)

Pagina fine

• 1268 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 42 (literal)

Rivista

• Amino acids (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Department of Pharmacology, Chemotherapy and Medical Toxicology, Università degli Studi di Milano, Via Vanvitelli, 32, 20129 Milan, Italy. 2 Division of Pharmacology and Toxicology, Department of Biomedical Sciences and Biotechnology, Università degli Studi di Brescia, Brescia, Italy. 3 Institute of Neurobiology and Molecular Medicine, CNR, Via del Fosso di Fiorano 64/65, Rome, Italy. 4 Department of Neuroscience, University \"Tor Vergata\", Rome, Italy (literal)

Titolo

• Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats (literal)

Abstract

• TLQP-21, a vgf-derived peptide modulates gastric emptying and prevents ethanol-induced gastric lesions in rats. However, it remains to be studied whether or not TLQP-21 affects gastric acid secretion. In this study, we evaluated the effects of central (0.8-8 nmol/rat) or peripheral (48-240 nmol/kg, intraperitoneally) TLQP-21 administration on gastric acid secretion in pylorus-ligated rats. The mechanisms involved in such activity were also examined. Central TLQP-21 injection significantly reduced gastric acid volume and dose-dependently inhibited total acid output (ED(50) = 2.71 nmol), while peripheral TLQP-21 administration had no effect. The TLQP-21 antisecretory activity was prevented by cysteamine (300 mg/kg, subcutaneously), a depletor of somatostatin, by indomethacin (0.25 mg/rat, intracerebroventricularly), a non-selective cyclooxygenase inhibitor, and by functional ablation of sensory nerves by capsaicin. We conclude that TLQP-21 could be considered a new member of the large group of regulatory peptides affecting gastric acid secretion. The central inhibitory effect of TLQP-21 on gastric acid secretion is mediated by endogenous somatostatin and prostaglandins and requires the integrity of sensory nerve fibres. (literal)

Prodotto di

• ex SV.P15.006.001 / Sviluppo, Differenziamento e Trasformazione Cellulare (SV.P15.006.002) (Modulo)

Autore CNR

• Roberta Possenti (Persona)

Insieme di parole chiave

• Keywords of "Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• Roberta Possenti (Persona)

Prodotto

• ex SV.P15.006.001 / Sviluppo, Differenziamento e Trasformazione Cellulare (SV.P15.006.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Amino acids (Rivista)

Insieme di parole chiave di

• Keywords of "Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats" (Insieme di parole chiave)