Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21 (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21 (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Possenti Roberta1,2; Muccioli Giampiero3; Petrocchi Pamela1,2; Cero Cheryl4,5; Cabassi Aderville6; Vulchanova Lucy7; Riedl Maureen S. 8; Manieri Monia9; Frontini Andrea9; Giordano Antonio9; Cinti Saverio9; Govoni Paolo10; Graiani Gallia11; Quaini Federico11; Ghè Corrado3; Bresciani Elena12; Bulgarelli Ilaria12; Torsello Antonio12; Locatelli Vittorio12; Sanghez Valentina5; Larsen Bjarne D.13; Petersen Jorgen S.13;Palanza Paola 5; Parmigiani Stefano5; Moles Anna1,14; Levi Andrea1; Bartolomucci Alessandro 4,5 (2012)
  Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21
  in Biochemical journal (Lond., 1984)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Possenti Roberta1,2; Muccioli Giampiero3; Petrocchi Pamela1,2; Cero Cheryl4,5; Cabassi Aderville6; Vulchanova Lucy7; Riedl Maureen S. 8; Manieri Monia9; Frontini Andrea9; Giordano Antonio9; Cinti Saverio9; Govoni Paolo10; Graiani Gallia11; Quaini Federico11; Ghè Corrado3; Bresciani Elena12; Bulgarelli Ilaria12; Torsello Antonio12; Locatelli Vittorio12; Sanghez Valentina5; Larsen Bjarne D.13; Petersen Jorgen S.13;Palanza Paola 5; Parmigiani Stefano5; Moles Anna1,14; Levi Andrea1; Bartolomucci Alessandro 4,5 (literal)

Pagina inizio

• 511 (literal)

Pagina fine

• 522 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 441 (literal)

Rivista

• Biochemical journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Institute of Cell Biology and Neurobiology, National Research Council and Fondazione Santa Lucia, Rome, Italy. 2 Department of Neuroscience, University of Roma II – Tor Vergata, Rome, Italy. 3 Department of Drug Science and Technology, University of Turin, Turin, Italy. 4 Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, U.S.A. 5 Department of Evolutionary and Functional Biology, University of Parma, Parma, Italy. 6 Department of Internal Medicine, Nephrology and Health Sciences, University of Parma, Parma, Italy. 7 Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN 55108, U.S.A. 8 Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, U.S.A. 9 Department of Molecular Pathology, Marche Polytechnic University, Ancona, Italy. 10 Department of Experimental Medicine, University of Parma, Parma, Italy. 11 Department Internal Medicine, University of Parma, Parma, Italy. 12 Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy. 13 Zealand Pharma A/S, Glostrup, Denmark. 14 Genomnia srl, Lainate, Italy. (literal)

Titolo

• Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21 (literal)

Abstract

• The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scrutinized as biomarkers for human disease. An endocrine/neuromodulatory role for VGF peptides has been suggested but never demonstrated. Furthermore, no study has demonstrated so far the existence of a receptor-mediated mechanism for any VGF peptide. In the present study, we provide a comprehensive in vitro, ex vivo and in vivo identification of a novel pro-lipolytic pathway mediated by the TLQP-21 peptide. We show for the first time that VGF-immunoreactivity is present within sympathetic fibres in the WAT (white adipose tissue) but not in the adipocytes. Furthermore, we identified a saturable receptor-binding activity for the TLQP-21 peptide. The maximum binding capacity for TLQP-21 was higher in the WAT as compared with other tissues, and selectively up-regulated in the adipose tissue of obese mice. TLQP-21 increases lipolysis in murine adipocytes via a mechanism encompassing the activation of noradrenaline/²-adrenergic receptors pathways and dose-dependently decreases adipocytes diameters in two models of obesity. In conclusion, we demonstrated a novel and previously uncharacterized peripheral lipolytic pathway encompassing the VGF peptide TLQP-21. Targeting the sympathetic nerve-adipocytes interaction might prove to be a novel approach for the treatment of obesity-associated metabolic complications (literal)

Prodotto di

• ex SV.P15.006.001 / Sviluppo, Differenziamento e Trasformazione Cellulare (SV.P15.006.002) (Modulo)

Autore CNR

• Roberta Possenti (Persona)
• ANNA MOLES (Unità di personale interno)
• ANDREA LEVI (Persona)

Insieme di parole chiave

• Keywords of "Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANDREA LEVI (Persona)
• ANNA MOLES (Unità di personale interno)
• Roberta Possenti (Persona)

Prodotto

• ex SV.P15.006.001 / Sviluppo, Differenziamento e Trasformazione Cellulare (SV.P15.006.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biochemical journal (Rivista)

Insieme di parole chiave di

• Keywords of "Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21" (Insieme di parole chiave)