http://www.cnr.it/ontology/cnr/individuo/prodotto/ID59323

Adipoparacrinology - vascular periadventitial adipose tissue (tunica adiposa) as an example (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Adipoparacrinology - vascular periadventitial adipose tissue (tunica adiposa) as an example (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1042/CBI20110422 (literal)

Alternative label

Chaldakov George N.1; Beltowsky Jerzy2; Ghenev Peter I.3; Fiore Marco4; Panayotov Plamen5, Rancic Gorana6,4; Aloe L. 4 (2012)
Adipoparacrinology - vascular periadventitial adipose tissue (tunica adiposa) as an example
in Cell biology international (Print)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Chaldakov George N.1; Beltowsky Jerzy2; Ghenev Peter I.3; Fiore Marco4; Panayotov Plamen5, Rancic Gorana6,4; Aloe L. 4 (literal)

Pagina inizio

327 (literal)

Pagina fine

330 (literal)

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36 (literal)

Rivista

Cell biology international (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

(*) L'INMM è stato soppresso il 12/1/2011 con provvedimento prot. n. 0002122 ed è confluito nell'IBCN costituito il 21/12/2010 con provvedimento prot. n. 0091899. (literal)

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3 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Note

PubMe (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1 Laboratory of Cell Biology, Medical University, Varna, Bulgaria. 2 Department of Pathophysiology, Medical University, Lublin, Poland. 3 Department of General and Clinical Pathology, Medical University, Varna, Bulgaria. 4 Institute of Neurobiology and Molecular Medicine, National Research Council CNR, Rome, Italy(*) 5 Cardiovascular Surgery Clinic, University St. Marina Hospital, Varna, Bulgaria. 6 Department of Histology and Embryology, Medical Faculty, University of Ni, Ni, Serbia. (literal)

Titolo

Adipoparacrinology - vascular periadventitial adipose tissue (tunica adiposa) as an example (literal)

Abstract

Human adipose tissue is partitioned into two large depots (subcutaneous and visceral), and many small depots associated with internal organs, e.g. heart, blood vessels, major lymph nodes, pancreas, prostate gland and ovaries. Since the adipose 'Big Bang' led to the discovery of leptin (Zhang, Proenca, Maffei, Barone, Leopold and Friedman, Nature 1994;372:425-32), adipose tissue has been seen not merely as a lipid store, but as a secretory - endocrine and paracrine - organ, particularly in the pathogenesis of a number of diseases. Accordingly, two major sub-fields of adipobiology have emerged, viz. adipoendocrinology and adipoparacrinology, the latter herein being illustrated by PAAT (periadventitial adipose tissue) in vascular walls. A long-standing paradigm holds that the vascular wall consists of three coats, tunica intima, tunica media and tunica adventitia. It is now imperative that 'to further elucidate vascular function, we should no longer, as hitherto, separate adventitia and PAAT from the vascular wall, but keep them attached and in place, and subject to thorough examination' (Chaldakov, Fiore, Ghenev, Stankulov and Aloe, Int Med J 2000;7:43-9; Chaldakov, Stankulov and Aloe, Atherosclerosis 2001;154:237-8; Chaldakov GN, Stankulov IS, Fiore M, Ghenev PI and Aloe L, Atherosclerosis 2001;159:57-66). From the available data, we propose that it is time to rethink about vascular wall composition, and suggest that the PAAT may be considered the fourth and outermost vascular coat, hence, tunica adiposa (regarding the proximal segment of coronary artery, it is the innermost part of the EAT (epicardial adipose tissue) situated around the coronary adventitia). Its significance in the pathogenesis and therapy of CMDs (cardiometabolic diseases), particularly atherosclerosis and hypertension, requires further basic, translational and clinical studies. (literal)

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