Targeting microRNAs in neurons: Tools and perspectives (Articolo in rivista)

Type
Label
  • Targeting microRNAs in neurons: Tools and perspectives (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Francesca Ruberti a; Christian Barbato a,b; Carlo Cogoni c (2012)
    Targeting microRNAs in neurons: Tools and perspectives
    in Experimental neurology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Francesca Ruberti a; Christian Barbato a,b; Carlo Cogoni c (literal)
Pagina inizio
  • 419 (literal)
Pagina fine
  • 426 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://dx.doi.org/10.1016/j.expneurol.2011.10.031 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 235 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • 2011 Nov 6. [Epub ahead of print] (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a - IBCN-Institute of Cell Biology and Neurobiology, CNR--National Research Council, Via del Fosso di Fiorano, 64/65, 00143, Roma, Italy. b - EBRI-European Brain Research Institute, Fondazione EBRI, Rita Levi-Montalcini, Via del Fosso di Fiorano, 64/65, 00143 Roma, Italy. c - Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Università di Roma \"La Sapienza\" Viale Regina Elena, 324, 00161 Roma, Italy. (literal)
Titolo
  • Targeting microRNAs in neurons: Tools and perspectives (literal)
Abstract
  • In the past few years, the understanding of microRNA (miRNA) biogenesis, the molecular mechanisms by which miRNAs regulate gene expression, and the functional roles of miRNAs has been expanded. Interestingly, numerous miRNAs are expressed in a spatially and temporally controlled manner in the nervous system, suggesting that their post-transcriptional regulation may be particularly relevant in neural development and function. miRNA studies in neurobiology have shown their involvement in synaptic plasticity and brain diseases. Approaches for manipulating miRNA levels in neuronal cells in vitro and in vivo are described here. Recent applications of miRNA antisense oligonucleotides, miRNA gene knockout and miRNA sponges in neuronal cells are reviewed. Finally, miRNA-based therapies for neurological pathologies related to alterations in miRNA functions are discussed. (literal)
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