Intensification of maternal care by double-mothering selectively boosts cognitive function and hippocampal morphology in the adult offspring (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Intensification of maternal care by double-mothering selectively boosts cognitive function and hippocampal morphology in the adult offspring (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• D'Amato F.R.1, Zanettini C.1, Sgobio C.2, Sarli C.1, Carone V.1, Moles A.1,2, Ammassari-Teule M.1,2 (2011)
  Intensification of maternal care by double-mothering selectively boosts cognitive function and hippocampal morphology in the adult offspring
  in Hippocampus (N.Y.N.Y., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D'Amato F.R.1, Zanettini C.1, Sgobio C.2, Sarli C.1, Carone V.1, Moles A.1,2, Ammassari-Teule M.1,2 (literal)

Pagina inizio

• 298 (literal)

Pagina fine

• 308 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• Hippocampus (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• (*) L'Unità Operativa di Servizio dell'Istituto di Neuroscienze di Roma è stata soppressa il 12/1/2011 con provvedimento prot. n. 0002130 ed è confluita nell'IBCN, costituito il 21/12/2010 con provvedimento prot. n. 0091899. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 - CNR Institute of Neuroscience, Rome, Italy(*); 2 - Department of Experimental Neurology, Santa Lucia Foundation, Rome, Italy (literal)

Titolo

• Intensification of maternal care by double-mothering selectively boosts cognitive function and hippocampal morphology in the adult offspring (literal)

Abstract

• Mice born from high care-giving females show, as adults, low anxiety levels, decreased responsiveness to stress, and substantial improvements in cognitive function and hippocampal plasticity. Given the relevance of this issue for preventing emotional and cognitive abnormalities in high-risk subjects, this study examines the possibility to further enhance the beneficial effects observed in the progeny by augmenting maternal care beyond the highest levels females can display in standard laboratory conditions. This was produced by placing a second female with the dam and its litter in the rearing cage from the partum until pups weaning. Maternal behavior of all females was scored during the first week postpartum, and behavioral indices of emotionality, prestress and poststress corticosterone levels, cognitive performance, and hippocampal morphology were assessed in the adult offspring. We found that pups reared by female dyads received more maternal care than pups reared by dams alone, but as adults, they did not exhibit alterations in emotionality or corticosterone response estimated in basal condition or following restraint stress. Conversely, they showed enhanced performance in hippocampal-dependent tasks including longterm object discrimination, reactivity to spatial change, and fear conditioning together with an increase in dendritic length and spine density in the CA1 region of the hippocampus. In general, the beneficial effects of dyadic maternal care were stronger when both the females were lactating. This study demonstrates that double-mothering exerts a longterm positive control on cognitive function and hippocampal neuronal connectivity. This experimental manipulation, especially if associated with increased feeding, might offer a concrete possibility to limit or reverse the consequences of negative predisposing conditions for normal cognitive development. (literal)

Prodotto di

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Autore CNR

• ANNE MARIE TEULE (Persona)
• FRANCESCA ROMANA D'AMATO (Persona)
• ANNA MOLES (Unità di personale interno)

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• Parole chiave di "Intensification of maternal care by double-mothering selectively boosts cognitive function and hippocampal morphology in the adult offspring" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANNE MARIE TEULE (Persona)
• ANNA MOLES (Unità di personale interno)
• FRANCESCA ROMANA D'AMATO (Persona)

Prodotto

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Hippocampus (Rivista)

Insieme di parole chiave di

• Parole chiave di "Intensification of maternal care by double-mothering selectively boosts cognitive function and hippocampal morphology in the adult offspring" (Insieme di parole chiave)