Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation (Articolo in rivista)

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Label
  • Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/cdd.2011.205 (literal)
Alternative label
  • R. Rizzi 1,2; E. Di Pasquale 2,3; P. Portararo 2; R. Papait 2,3; P. Cattaneo 2,3; M.V.G. Latronico 2; C. Altomare 4; L. Sala 4; A. Zaza 4; E. Hirsch 5; L. Naldini 6; G. Condorelli 7,8; C. Bearzi 1,2 (2012)
    Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation
    in Cell death and differentiation
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • R. Rizzi 1,2; E. Di Pasquale 2,3; P. Portararo 2; R. Papait 2,3; P. Cattaneo 2,3; M.V.G. Latronico 2; C. Altomare 4; L. Sala 4; A. Zaza 4; E. Hirsch 5; L. Naldini 6; G. Condorelli 7,8; C. Bearzi 1,2 (literal)
Pagina inizio
  • 1162 (literal)
Pagina fine
  • 1174 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 19 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • 2012 Jan 20. doi: 10.1038/cdd.2011.205. [Epub ahead of print] (literal)
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  • 12 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Cell Biology and Neurobiology Institute, National Research Council of Italy (CNR), Roma, Italy; 2 Istituto Ricovero Cura Carattere Scientifico MultiMedica, Milan, Italy; 3 Institute of Genetic and Biomedical Research, National Research Council of Italy (CNR), Milan, Italy; 4 Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Milan, Italy; 5 Department of Genetics, Biology and Biochemistry and Molecular Biotechnology Center, University of Torino, Torino, Italy; 6 Fondazione San Raffaele Monte Tabor, Milan, Italy; 7 Department of Medicine, University of California San Diego, La Jolla, CA, USA; 8 Department of Medicine, CNR, Milan, Italy. (literal)
Titolo
  • Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation (literal)
Abstract
  • Adult mammalian cells can be reprogrammed to a pluripotent state by forcing the expression of a few embryonic transcription factors. The resulting induced pluripotent stem (iPS) cells can differentiate into cells of all three germ layers. It is well known that post-natal cardiomyocytes (CMs) lack the capacity to proliferate. Here, we report that neonatal CMs can be reprogrammed to generate iPS cells that express embryonic-specific markers and feature gene-expression profiles similar to those of mouse embryonic stem (mES) cell and cardiac fibroblast (CF)-derived iPS cell populations. CM-derived iPS cells are able to generate chimeric mice and, moreover, re-differentiate toward CMs more efficiently then either CF-derived iPS cells or mES cells. The increased differentiation capacity is possibly related to CM-derived iPS cells retaining an epigenetic memory of the phenotype of their founder cell. CM-derived iPS cells may thus lead to new information on differentiation processes underlying cardiac differentiation and proliferation. (literal)
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