Synthesis of new Praziquantel analogues: Potential candidates for the treatment of schistosomiasis (Articolo in rivista)

Type
Label
  • Synthesis of new Praziquantel analogues: Potential candidates for the treatment of schistosomiasis (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bmcl.2011.11.108 (literal)
Alternative label
  • Partha Sarathi Sadhu a; Singam Naveen Kumar a; Malapaka Chandrasekharam b; Livia Pica-Mattoccia c; Donato Cioli c; Vaidya Jayathirtha Rao a (2012)
    Synthesis of new Praziquantel analogues: Potential candidates for the treatment of schistosomiasis
    in Bioorganic & medicinal chemistry letters (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Partha Sarathi Sadhu a; Singam Naveen Kumar a; Malapaka Chandrasekharam b; Livia Pica-Mattoccia c; Donato Cioli c; Vaidya Jayathirtha Rao a (literal)
Pagina inizio
  • 1103 (literal)
Pagina fine
  • 1106 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Received 26 September 2011; revised 5 November 2011; Accepted 28 November 2011. Available online 13 December 2011. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a - Organic Chemistry Division II, Indian Institute of Chemical Technology, Uppal Road Tarnaka, Hyderabad 500607, India. b - Inorganic & Physical Chemistry Division, Indian Institute of Chemical Technology, Uppal Road Tarnaka, Hyderabad 500607, India. c - Institute of Cell Biology and Neurobiology, National Research Council, 00015 Monterotondo, Rome, Italy. (literal)
Titolo
  • Synthesis of new Praziquantel analogues: Potential candidates for the treatment of schistosomiasis (literal)
Abstract
  • An efficient Synthesis of antischistosomal drug Praziquantel and analogues was achieved and the synthetic route designed was to afford structurally diverse analogues for better structure–activity relationship understanding. Total of nineteen PZQ analogues with structural variations at amide, piperazine and aromatic moieties have been synthesized and fully characterized. Among all the new analogues tested for antischistosomal activity, one dimethoxy tetrahydroisoquinoline analogue and two tetrahydro-beta-carboline analogues exhibited modearate activity against adult Schistosomamansoni. Tetrahydro-beta-carboline analogues showed moderate activity whereas the presence of p-trifluoromethylbenzoyl and p-toluenesulphonyl moieties resulted in complete suppression of antischistosomal activity. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it