A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Barbagallo A. P. M. 1, Wang Z. 2, Zheng H. 2, D'Adamio L. 3 (2011)
  A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Barbagallo A. P. M. 1, Wang Z. 2, Zheng H. 2, D'Adamio L. 3 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Received January 10, 2011 Accepted January 25, 2011 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 - Department of Microbiology and Immunology, Einstein College of Medicine, Bronx, New York 10461, USA; 2 - Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA; 3 - Institute of Cellular Biology and Neurobiology, National Research Council of Italy, via del Fosso del Fiorano, 64, 00143 Roma, Italy (literal)

Titolo

• A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function (literal)

Abstract

• The APP intracellular domain (AID) is highly conserved and contains many potentially important residues, in particular the 682YENPTY687 motif. To dissect the function of this sequence in vivo, we created an APP knock-in allele mutating Y682 to Gly (Y682G). Crossing this allele to APP-like protein 2 (APLP2) knockout background showed that, mutation of Y682 results in postnatal lethality and neuromuscular synapse defects similar to doubly deficient APP/APLP2 mice. Our results demonstrate that a single residue in the APP intracellular region, Y682, is indispensible for the essential function of APP in developmental regulation. (literal)

Prodotto di

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)

Autore CNR

• Luciano D'Adamio (Unità di personale esterno)

Insieme di parole chiave

• Parole chiave di "A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function" (Insieme di parole chiave)

Incoming links:

Prodotto

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)

Autore CNR di

• Luciano D'Adamio (Unità di personale esterno)

Insieme di parole chiave di

• Parole chiave di "A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function" (Insieme di parole chiave)