Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1080/17470919.2010.482786 (literal)

Alternative label

• Troisi A.a, Frazzetto G.b, Carola V.b,c, Di Lorenzo G.a, Coviello M.a,b, D'Amato F.R.d, Moles A.d,e, Siracusano A.a, Gross C.b (2011)
  Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients
  in Social neuroscience (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Troisi A.a, Frazzetto G.b, Carola V.b,c, Di Lorenzo G.a, Coviello M.a,b, D'Amato F.R.d, Moles A.d,e, Siracusano A.a, Gross C.b (literal)

Pagina inizio

• 88 (literal)

Pagina fine

• 98 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 6 (literal)

Rivista

• Social neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• (*) L'Unità Operativa di Servizio dell'Istituto di Neuscienze di Roma è stata soppressa il 12/1/2011 con provvedimento prot. n. 0002130 ed è confluita nell'IBCN, costituito il 21/12/2010 con provvedimento prot. n. 91899. (literal)

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• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a - University of Rome Tor Vergata, Rome, Italy; b - European Molecular Biology Laboratory, Monterotondo, Italy; c - European Centre for Brain Research (CERC), Rome, Italy; d - Institute of Neurosciences (*), CNR, Rome, Italy; e - Genomnia, Lainate, Italy (literal)

Titolo

• Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients (literal)

Abstract

• A large body of evidence links altered opioid signaling with changes in social behavior in animals. However, few studies have attempted to determine whether similar links exist in humans. Here we investigate whether a common polymorphism (A118G) in the mu-opioid receptor gene (OPRM1) is associated with alterations in personality traits linked to affiliative behavior and attachment. In a mixed sample (N = 214) of adult healthy volunteers and psychiatric patients, we analyzed the association between the A118G polymorphism of the OPRM1 and two different psychological constructs reflecting individual differences in the capacity to experience social reward. Compared to individuals expressing only the major allele (A) of the A118G polymorphism, subjects expressing the minor allele (G) had an increased tendency to become engaged in affectionate relationships, as indicated by lower scores on a self-report measure of avoidant attachment, and experienced more pleasure in social situations, as indicated by lower scores on a self-report measure of social anhedonia. The OPRM1 variation accounted for about 3.5% of the variance in the two measures. The significant association between the A118G polymorphism and social hedonic capacity was independent of the participants' mental health status. The results reported here are in agreement with the brain opioid hypothesis of social attachment and the established role of opioid transmission in mediating affiliative behavior. (literal)

Prodotto di

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Autore CNR

• FRANCESCA ROMANA D'AMATO (Persona)
• ANNA MOLES (Unità di personale interno)

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• Parole chiave di "Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANNA MOLES (Unità di personale interno)
• FRANCESCA ROMANA D'AMATO (Persona)

Prodotto

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Social neuroscience (Rivista)

Insieme di parole chiave di

• Parole chiave di "Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients" (Insieme di parole chiave)