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A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques (Articolo in rivista)

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A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques (Articolo in rivista) (literal)

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Cirulli F. a, Reif A. b, Herterich S. c, Lesch K.P. b, Berry A. a, Francia N. a, Aloe L. d, Barr C.S. e, Suomi S.J. f, Alleva E. a (2011)
A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques
in Psychoneuroendocrinology
(literal)

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Cirulli F. a, Reif A. b, Herterich S. c, Lesch K.P. b, Berry A. a, Francia N. a, Aloe L. d, Barr C.S. e, Suomi S.J. f, Alleva E. a (literal)

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(*) L'INMM è stato soppresso il 12/1/2011 con provvedimento prot. n. 0002122 ed è confluito nell'IBCN costituito il 21/12/2010 con provvedimento prot. n. 0091899. (literal)

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a - Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161 Rome, Italy; b - Unit for Molecular Psychiatry (UMP) Dept. of Psychiatry and Psychotherapy, University of Würzburg, Füchsleinstr. 15, Würzburg, Germany; c - Central Laboratory, Department of Clinical Biochemistry and Pathobiochemistry, Julius-Maximilians-University, Würzburg, Germany; d - Institute of Neurobiology and Molecular Medicine, CNR (*) / EBRI, Via Fosso di Fiorano, 64/65, 00143 Rome, Italy; e - Section of Comparative Behavioral Genomics, NIAAA, Rockville, MD 20852, USA; f - Laboratory of Comparative Ethology, NICHD, Poolesville, MD 20837, USA. (literal)

Titolo

A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques (literal)

Abstract

Early stressful events can increase vulnerability for psychopathology, although knowledge on the effectors is still limited. In this report we describe the characterization of a single nucleotide polymorphism (SNP) in rhesus macaques, which results in a Val to Met transition in the pro-BDNF domain, similar to a well described variant in the human gene. Further, we tested the hypothesis that peripheral levels of BDNF, which is involved in the response to stress and in the pathophysiology of anxiety and depression, might be differentially affected in a non-human primate model of early adverse rearing in a genotype-dependent manner. Males and females rhesus macaques reared either with their mothers (MR), in peer-only groups (PR), or in a \"surrogate/peer-reared\" (SPR) condition with limited peer interactions, were used as experimental subjects. BDNF levels were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA procedure. Data indicate that BDNF levels were increased as a result of peer-rearing and that this increase was moderated by the presence of the SNP. Overall these data indicate that a SNP, which results in a Val to Met transition in the pro-BDNF domain, is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene. (literal)

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