Viral-mediated expression of a constitutively active form of CREB in the dentate gyrus does not induce abnormally enduring fearmemory (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Viral-mediated expression of a constitutively active form of CREB in the dentate gyrus does not induce abnormally enduring fearmemory (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Vetere G.1,2, Marchetti C.3, Benevento M.3, Tafi E.3, Marie H.3, Ammassari-Teule M.1,2 (2011)
  Viral-mediated expression of a constitutively active form of CREB in the dentate gyrus does not induce abnormally enduring fearmemory
  in Behavioural brain research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vetere G.1,2, Marchetti C.3, Benevento M.3, Tafi E.3, Marie H.3, Ammassari-Teule M.1,2 (literal)

Pagina inizio

• 394 (literal)

Pagina fine

• 396 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 222 (literal)

Rivista

• Behavioural brain research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Epub 2011 Apr 12 - Issue 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 - Cell Biology and Neurobiology Institute, CNR, National Research Council, Rome, Italy. 2 - Santa Lucia Foundation, Rome, Italy. 3 - Laboratory of Molecular Mechanisms of Synaptic Plasticity, European Brain Research Institute, Rome, Italy. (literal)

Titolo

• Viral-mediated expression of a constitutively active form of CREB in the dentate gyrus does not induce abnormally enduring fearmemory (literal)

Abstract

• Increasing CREB-dependent transcription in dentate gyrus (DG) granule cells in vivo using viral-mediated expression of a constitutively active form of CREB (CREBCA) is sufficient to enhance contextual fear memory but whether this treatment renders memory abnormally enduring is unknown. Here we confirm that over-expressing CREBCA in the DG increases retention of contextual fear conditioning (CFC) and show that this memory decays normally. Specifically, the retention scores of CREBCA mice are significantly higher than those of GFP-infected controls 24h after the conditioning, but match them after a longer exposure session and are still in the same range 48 h later. Our findings provide evidence that boosting selectively CREB activity in the DG promotes the formation of a stronger memory trace but does not increase its resistance to extinguish. (literal)

Prodotto di

• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)

Autore CNR

• GISELLA VETERE (Unità di personale esterno)
• ANNE MARIE TEULE (Persona)

Incoming links:

Autore CNR di

• ANNE MARIE TEULE (Persona)
• GISELLA VETERE (Unità di personale esterno)

Prodotto

• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Behavioural brain research (Rivista)