Drug Resistance Among Drug-naive and First-line Antiretroviral Treatment-failing Children in Cameroon. (Articolo in rivista)

Type
Label
  • Drug Resistance Among Drug-naive and First-line Antiretroviral Treatment-failing Children in Cameroon. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Fokam J, Salpini R, Santoro MM, Cento V, Perno CF, Colizzi V, Ndumbe PM, Fokunang Ntungen C, Ndiang Tetang SM, Nanfack AJ, Takou Komego DA, *Cappelli G. (2011)
    Drug Resistance Among Drug-naive and First-line Antiretroviral Treatment-failing Children in Cameroon.
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Fokam J, Salpini R, Santoro MM, Cento V, Perno CF, Colizzi V, Ndumbe PM, Fokunang Ntungen C, Ndiang Tetang SM, Nanfack AJ, Takou Komego DA, *Cappelli G. (literal)
Pagina inizio
  • 1062 (literal)
Pagina fine
  • 1068 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 30 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé, Cameroon; Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon; Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy; Department of Biology, University of Rome Tor Vergata, Rome, Italy; IRCSS Lazarro Spallanzani, Rome, Italy; Faculty of Health Sciences, University of Buea, Buea, Cameroon; Pediatric Unit, National Social Insurance Centre Hospital, Yaoundé, Cameroon; *Institute of Translational Pharmacology, National Research Council, Rome, Italy. (literal)
Titolo
  • Drug Resistance Among Drug-naive and First-line Antiretroviral Treatment-failing Children in Cameroon. (literal)
Abstract
  • BACKGROUND: Scale-up to antiretroviral therapy (ART) requires surveillance for HIV drug resistance. With the goal of attaining 100% pediatric ART coverage in Cameroon, strategies to limit the spread of HIV resistance among children are very important. METHODS: From June 2009 through February 2011, 92 HIV-1-infected children (41 ART-naive, 51 failing first-line ART) living in Yaoundé, Cameroon, were enrolled; HIV-1 Prot-RT genotypic resistance testing (GRT) was performed using an inhouse assay. Among 40 children failing first-line ART, treatment response was evaluated at weeks 24 and 48 after treatment was changed, based on GRT results. RESULTS: The mean age was 72 months both for children who were drug-naive and those failing ART (range: 3-144 and 12-144, respectively), with a mean viremia of 5.59 log and 4.71 log RNA copies/mL, a median CD4 of 17% (588 cells/¼L) and 23% (719 cells/¼L), respectively. Median time-to-treatment failure was 610 days. A prevalence of 4.9% and 90% drug resistance was observed, respectively, among children who were drug-naive and those failing first-line ART, with circulating recombinant form CRF02_AG as the most prevalent clade (58.6% and 62%, respectively). After a change to GRT-based treatment, more than 90% of children had viremia <3 log RNA copies/mL at week 24 and confirmed at week 48, with 70% achieving undetectable viremia, although without correlation to immune response; 97.5% had switched to lopinavir/ritonavir-containing regimens. CONCLUSION: HIV-1 drug resistance was low among ART-naive children and very high among those failing first-line ART. Treatment change based on GRT was successful for most children, with lopinavir/ritonavir regimens being very promising for second-line use. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
data.CNR.it