TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death. (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Maria Lucibello (a); Alessandra Gambacurta (b); Manuela Zonfrillo (a); Pasquale Pierimarchi (a); Annalucia Serafino (a); Guido Rasi (b); Anna Rubartelli (c); and Enrico Garaci (b). (2011)
  TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death.
  in Experimental cell research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Maria Lucibello (a); Alessandra Gambacurta (b); Manuela Zonfrillo (a); Pasquale Pierimarchi (a); Annalucia Serafino (a); Guido Rasi (b); Anna Rubartelli (c); and Enrico Garaci (b). (literal)

Pagina inizio

• 2479 (literal)

Pagina fine

• 2489 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Corresponding author: Dr. Maria Lucibello (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 317 (literal)

Rivista

• Experimental cell research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 17 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a) Institute of Translational Pharmacology, National Research Council, Rome, Italy b) Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy c) Cell Biology Unit, National Cancer Research Institute, Genoa, Italy. (literal)

Titolo

• TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death. (literal)

Abstract

• The translationally controlled tumor protein (TCTP) displays growth-promoting and antiapoptotic properties. To gain information on the role of TCTP in cancer disease, we studied the modulation of TCTP and cell survival under stress conditions on tumor cell lines of different origin. When cancer cells were exposed to a mild oxidative stress, such low doses of Arsenic trioxide (ATO) or hydrogen peroxide (H2O2), up-regulation of TCTP was observed in cells survived to the treatment. Differently, a strong oxidative hit provided by ATO combined with glutathione (GSH) depletion or condition of glucose deprivation caused a down-modulation of TCTP followed by cell death. Clones with a forced expression of TCTP or with silenced TCTP were obtained from the breast cancer cell line MDA-MB-231. The sensitivity to oxidative stress was strongly enhanced in down-modulated TCTP cells while decreasing in cells with high levels of TCTP. Together these results indicate that TCTP is a survival factor that protects cancer cells from oxidative stress-induced cell-death. We propose TCTP as a “stress hallmark” that may be exploited as a therapeutic target to decrease the resistance of cancer cells to anticancer therapy. (literal)

Prodotto di

• Target molecolari, modelli preclinici ed immunoterapia in Oncologia (ME.P03.015.001) (Modulo)
• Ricerca traslazionale ed outcome nelle patologie infiammatorie e degenerative (ME.P04.009.001) (Modulo)

Autore CNR

• ANNALUCIA SERAFINO (Persona)
• PASQUALE PIERIMARCHI (Unità di personale interno)
• MARIA LUCIBELLO (Persona)

Insieme di parole chiave

• Parole chiave di "TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANNALUCIA SERAFINO (Persona)
• PASQUALE PIERIMARCHI (Unità di personale interno)
• MARIA LUCIBELLO (Persona)

Prodotto

• Target molecolari, modelli preclinici ed immunoterapia in Oncologia (ME.P03.015.001) (Modulo)
• Ricerca traslazionale ed outcome nelle patologie infiammatorie e degenerative (ME.P04.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Experimental cell research (Rivista)

Insieme di parole chiave di

• Parole chiave di "TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death." (Insieme di parole chiave)