A Novel pH-Responsive Nanogel for the Controlled Uptake and Release of Hydrophobic and Cationic Solutes (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A Novel pH-Responsive Nanogel for the Controlled Uptake and Release of Hydrophobic and Cationic Solutes (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/jp204954a (literal)

Alternative label

• Simona Argentiere; Laura Blasi; Giovanni Morello; Giuseppe Gigli (2011)
  A Novel pH-Responsive Nanogel for the Controlled Uptake and Release of Hydrophobic and Cationic Solutes
  in Journal of physical chemistry. C
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Simona Argentiere; Laura Blasi; Giovanni Morello; Giuseppe Gigli (literal)

Pagina inizio

• 16347 (literal)

Pagina fine

• 16353 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 115 (literal)

Rivista

• Journal of physical chemistry. C (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• DOI: 10.1021/jp204954a (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• NNL CNR Istituto Nanoscienze, Lecce Università del Salento, Lecce (literal)

Titolo

• A Novel pH-Responsive Nanogel for the Controlled Uptake and Release of Hydrophobic and Cationic Solutes (literal)

Abstract

• The study of the mechanisms underlying the uptake and release of bioactive molecules from stimuli-responsive nanoparticles is the key to their application in biomedical fields. Here, we present the pH-controlled uptake and release of two chemically different solutes from newly synthesized nanogels, showing their potential as pH-controlled dual drug delivery systems. Nanogels were synthesized by emulsion copolymerization of methacrylic acid (MAA) and methyl acrylate (MA), and then characterized by FT-IR, 1H NMR, and dynamic light scattering (DLS). To study the encapsulation and delivery properties of PMA-PMAA nanogels, a hydrophobic thiophene fluorophore (TF) and a cationic drug, doxorubicin (DX), were chosen. The uptake and release experiments were run at different pH values and monitored by absorption and both steady-state and time-resolved photoluminescence (PL) spectroscopy. Interestingly, the release of TF and DX was obtained under basic and acidic conditions, respectively, thus demonstrating a pH-controlled dual drug release by PMA-PMAA nanogels depending on the chemical nature of the tested solutes. (literal)

Prodotto di

• Nanobiotecnologie & Nanobioelettronica (MD.P06.008.004) (Modulo)
• Celle solari organiche e ibride (MD.P06.007.002) (Modulo)

Autore CNR

• LAURA BLASI (Persona)
• GIUSEPPE GIGLI (Persona)
• GIOVANNI MORELLO (Unità di personale esterno)
• SIMONA ARGENTIERE (Unità di personale esterno)

Insieme di parole chiave

• Parole chiave di "A Novel pH-Responsive Nanogel for the Controlled Uptake and Release of Hydrophobic and Cationic Solutes" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIOVANNI MORELLO (Unità di personale esterno)
• GIUSEPPE GIGLI (Persona)
• SIMONA ARGENTIERE (Unità di personale esterno)
• LAURA BLASI (Persona)

Prodotto

• Nanobiotecnologie & Nanobioelettronica (MD.P06.008.004) (Modulo)
• Celle solari organiche e ibride (MD.P06.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of physical chemistry. C (Rivista)

Insieme di parole chiave di

• Parole chiave di "A Novel pH-Responsive Nanogel for the Controlled Uptake and Release of Hydrophobic and Cationic Solutes" (Insieme di parole chiave)