Magnetic nanobeads decorated by thermo-responsive PNIPAM shell as medical platforms for the efficient delivery of doxorubicin to tumour cells (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Magnetic nanobeads decorated by thermo-responsive PNIPAM shell as medical platforms for the efficient delivery of doxorubicin to tumour cells (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Deka S.R., A. Quarta, R. Di Corato, A. Riedinger, R. Cingolani and T. Pellegrino (2011)
  Magnetic nanobeads decorated by thermo-responsive PNIPAM shell as medical platforms for the efficient delivery of doxorubicin to tumour cells
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Deka S.R., A. Quarta, R. Di Corato, A. Riedinger, R. Cingolani and T. Pellegrino (literal)

Pagina inizio

• 619 (literal)

Pagina fine

• 629 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• DOI: 10.1039/c0nr00570c Acknowledgment: This work was supported in part by the European project Magnifyco (Contract NMP4-SL-2009-228622). We thank Mario Malerba for TEM sample preparation and Dr Liberato Manna for helpful discussion. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• - Ist Italiano Tecnol, I-16163 Genoa, Italy (S.R. Deka, A. Quarta, A. Riedinger, R. Cingolani, T. Pellegrino) - CNR, NANO, Natl Nanotechnol Lab, I-73100 Lecce, Italy (A. Quarta, R. Di Corato, T. Pellegrino) (literal)

Titolo

• Magnetic nanobeads decorated by thermo-responsive PNIPAM shell as medical platforms for the efficient delivery of doxorubicin to tumour cells (literal)

Abstract

• Medical nanoplatforms based on clusters of superparamagnetic nanoparticles decorated with a PNIPAM thermo-responsive shell have been synthesized and used as drug carriers for doxorubicin (DOXO), a common chemotherapeutic agent. The nanosystem here developed has a total diameter below 200 nm and exploits the temperature responsive behaviour of the PNIPAM polymeric shell for the controlled loading and release of DOXO. The system has been tested in vitro on tumour cells and it clearly demonstrates the effectiveness of drug polymer encapsulation and time-dependent cell death induced by the doxorubicin release. Comparative cellular studies of the DOXO loaded nanoplatform in the presence or absence of an external magnet (0.3 T) showed the synergic effect of accumulation and enhanced toxicity of the system, when magnetically guided, resulting in the enhanced efficacy of the system. (literal)

Prodotto di

• Nanocompositi (MD.P06.015.002) (Modulo)

Autore CNR

• RICCARDO DI CORATO (Unità di personale esterno)
• ALESSANDRA QUARTA (Unità di personale interno)
• TERESA PELLEGRINO (Persona)

Insieme di parole chiave

• Parole chiave di "Magnetic nanobeads decorated by thermo-responsive PNIPAM shell as medical platforms for the efficient delivery of doxorubicin to tumour cells" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• TERESA PELLEGRINO (Persona)
• RICCARDO DI CORATO (Unità di personale esterno)
• ALESSANDRA QUARTA (Unità di personale interno)

Prodotto

• Nanocompositi (MD.P06.015.002) (Modulo)

Insieme di parole chiave di

• Parole chiave di "Magnetic nanobeads decorated by thermo-responsive PNIPAM shell as medical platforms for the efficient delivery of doxorubicin to tumour cells" (Insieme di parole chiave)