Superparamagnetic colloidal nanocrystal clusters coated with polyethylene glycol fumarate: a possible novel theranostic agent (Articolo in rivista)

Type
Label
  • Superparamagnetic colloidal nanocrystal clusters coated with polyethylene glycol fumarate: a possible novel theranostic agent (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Amiri H., M. Mahmoudi and A. Lascialfari (2011)
    Superparamagnetic colloidal nanocrystal clusters coated with polyethylene glycol fumarate: a possible novel theranostic agent
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Amiri H., M. Mahmoudi and A. Lascialfari (literal)
Pagina inizio
  • 1022 (literal)
Pagina fine
  • 1030 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 3 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • DOI: 10.1039/c0nr00603c Acknowledgment: The SQUID and NMR/MRI experiments have been performed with the funds from PUR2008 project from Universita degli Studi di Milano. M. Corti is gratefully acknowledged for his help in experimental measurements. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • - Inst Pasteur, Natl Cell Bank, Tehran, Iran (1. Inst Pasteur, Natl Cell Bank, Tehran, Iran - Univ Milan, Dept Mol Sci Appl Biosyst, I-20134 Milan, Italy (H. Amiri, A. Lascialfari) - Univ Pavia, Dept Phys A Volta, I-27100 Pavia, Italy (H. Amiri, A. Lascialfari) 4. CNR Ist Nanosci, Ctr S3, I-41125 Modena, Italy (A. Lascialfari) (literal)
Titolo
  • Superparamagnetic colloidal nanocrystal clusters coated with polyethylene glycol fumarate: a possible novel theranostic agent (literal)
Abstract
  • We report cell endocytosis, drug release, NMR relaxometry and in vitro MRI studies on a novel class of superparamagnetic colloidal nanocrystal clusters (CNCs) with various biocompatible coatings. It is shown that the transverse relaxivity r(2), the parameter representing the MRI efficiency in negative contrast agents, for the PVA-coated, PEGF-coated, and crosslinked PEGF-coated CNCs, is high enough to contrast suitably the magnetic resonance images. The same samples have shown a good ability also in drug releasing (particularly the crosslinked PEGF-coated compound), thus finally allowing us to propose this class of compounds for future applications in theranostics. (literal)
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