Nanotopographic Control of Neuronal Polarity (Articolo in rivista)

Type
Label
  • Nanotopographic Control of Neuronal Polarity (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/nl103349s (literal)
Alternative label
  • A. Ferrari, M. Cecchini, A. Dhawan, S. Micera, I. Tonazzini, R. Stabile, D. Pisignano, F. Beltram (2011)
    Nanotopographic Control of Neuronal Polarity
    in Nano letters (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • A. Ferrari, M. Cecchini, A. Dhawan, S. Micera, I. Tonazzini, R. Stabile, D. Pisignano, F. Beltram (literal)
Pagina inizio
  • 505 (literal)
Pagina fine
  • 511 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 11 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • DOI: 10.1021/nl103349s (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. NEST, Istituto Nanoscienze —CNR and Scuola Normale Superiore, Piazza San Silvestro, 12 I-56126 Pisa, Italy 2. School of Electrical and Computer Engineering, Cornell University, Ithaca, New York 14853, United States 3. NNL, Istituto Nanoscienze— CNR, IIT Center for Biomolecular Nanotechnologies, and Dipartimento di Ingegneria dell’'Innovazione, Università del Salento, via Arnesano, 73100, Lecce, Italy 4. ARTS Lab, Scuola Superiore Sant’Anna and Institute for Automation, Swiss Federal Institute of Technology Zurich, 8006 Zurich, Switzerland (literal)
Titolo
  • Nanotopographic Control of Neuronal Polarity (literal)
Abstract
  • We employ simple geometrical rules to design a set of nanotopographies able to interfere with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint lithography techniques on cyclic-olefin-copolymer films, we demonstrate that by varying a single topographical parameter the orientation and maturation of focal adhesions can be finely modulated yielding independent control over the final number and the outgrowth direction of neurites. Taken together, this report provides a novel and promising approach to the rational design of biocompatible textured substrates for tissue engineering applications. (literal)
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