Multilayered Polyelectrolyte Capsules and Coated Colloids: Cytotoxicity and Uptake by Cancer Cells (Articolo in rivista)

Type
Label
  • Multilayered Polyelectrolyte Capsules and Coated Colloids: Cytotoxicity and Uptake by Cancer Cells (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Palamà I.E., Coluccia A.M.L., Della Torre A., Vergaro V., Perrone E., Cingolani R., Rinaldi R. and Leporatti S. (2010)
    Multilayered Polyelectrolyte Capsules and Coated Colloids: Cytotoxicity and Uptake by Cancer Cells
    in Science and technology of advanced materials
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Palamà I.E., Coluccia A.M.L., Della Torre A., Vergaro V., Perrone E., Cingolani R., Rinaldi R. and Leporatti S. (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Univ Salento, Scuola Super ISUFI, CNR INFM, NNL,IIT Res Unit, I-73100 Lecce, Italy 2. SanofiAventis SpA, Zona Ex Punto Franco, I-72100 Brindisi, Italy (Palamà I.E., Coluccia A.M.L., Della Torre A., Vergaro V., Perrone E., Cingolani R., Rinaldi R. and Leporatti S.) (literal)
Titolo
  • Multilayered Polyelectrolyte Capsules and Coated Colloids: Cytotoxicity and Uptake by Cancer Cells (literal)
Abstract
  • The internalisation efficiency and cytotoxicity of polymeric microparticles and capsules were studied for three different adherent cell lines: HeLa (human cervice cancer), MCF-7 (human breast cancer) and B104 (murine neuroblastoma). Microparticles of colloidal CaCO3 cores coated with either layerby- layer self-assembled oppositely charged biosynthetic (PSS\PAH) or biodegradable (DXS\PRM) polyelectrolytes and hollow capsules thereof, obtained upon removal of the CaCO3 cores by EDTA, were fabricated. Fluorescent-labeled polymer layers coated onto CaCO3 cores were employed for evaluating cell uptake efficiency. Confocal laser scanning microscopy was used to confirm dissolution of preformed biodegradable multilayers. Cellular viability for all type of colloidal entities was preserved, indicating safety and tolerability of the potential drug carriers. (literal)
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