http://www.cnr.it/ontology/cnr/individuo/prodotto/ID58855

Cytocompatibility and Uptake of Halloysite Clay Nanotubes (Articolo in rivista)

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Cytocompatibility and Uptake of Halloysite Clay Nanotubes (Articolo in rivista) (literal)

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Vergaro V., Abdullayev E. , Lvov Y.M., Zeitoun A., Cingolani R., Rinaldi R. and Leporatti S. (2010)
Cytocompatibility and Uptake of Halloysite Clay Nanotubes
in Biomacromolecules
(literal)

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Vergaro V., Abdullayev E. , Lvov Y.M., Zeitoun A., Cingolani R., Rinaldi R. and Leporatti S. (literal)

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Acknowledgement: Financial Support of Italian Ministry of University and Research (MIUR) through FIRB project no. RBLA03ER38 is gratefully acknowledged. \"Con il contributo del Ministero degli Affari Esteri, Direzione Generale per la promozione e la Cooperazione Sociale \"(Italy-USA Bilateral Project \"Nano-Carriers for Cancer Therapy\"). We acknowledge Applied Minerals, Inc. for providing halloysite and David Mills (Louisiana Tech University) for data concerning halloysite boric implants. Support by Louisiana Board of Regent grant LEQSF-2009RD is acknowledged. (literal)

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1. Univ Salento, Lecce Unit, Italian Inst Technol, INFM,CNR,NNL, I-73100 Isufi Lecce, Italy (Vergaro V., Cingolani R., Rinaldi R., Leporatti S.) 2. Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71272 USA (Abdullayev E., Lvov Y.M.) 3. Louisiana Tech Univ, Biomed Engn Program, Ruston, LA 71272 USA (Abdullayev E., Lvov Y.M.) 4. Appl Minerals Inc, New York, NY USA Vergaro (Zeitoun A.) (literal)

Titolo

Abstract

Halloysite is aluminosilicate clay With hollow tubular structure of 50 lint external diameter and 15 nm diameter)lumen. Halloysite biocompatibility study is important for its potential applications in polymer composites, boric implants, controlled drug delivery, and for protective coating (e.g., anticorrosion or antimolding). Halloysite nanotubes were added to different cell cultures for toxicity tests. Its fluorescence functionalization by aminopropyltriethosilane (APTES) and With fluorescently labeled polyelectrolyte layers allowed following halloysite uptake by the cells with confocal laser scanning microscopy (CLSM). Quantitative Trypan blue and MTT measurements performed with two neoplastic cell lines model systems as a function of the nanotubes concentration and incubation time indicate that halloysite exhibits a high level of biocompatibility and very low cytotoxicity, rendering it it good candidate for household materials zinc] medicine. A combination of transmission electron microscopy (TEM), scanning electron microscopy (SI-E-M), and scanning force microscopy (SFM) imaging techniques have been employed to elucidate the Structure of halloysite nanotubes. (literal)

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