Flexibility and drug release features of lipid/saccharide nanoparticles (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Flexibility and drug release features of lipid/saccharide nanoparticles (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/b916139b (literal)

Alternative label

• Gerelli Y., Di Bari M.T., Barbieri S., Sonvico F., Colombo P., Natali F., Deriu A (2010)
  Flexibility and drug release features of lipid/saccharide nanoparticles
  in Soft matter (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gerelli Y., Di Bari M.T., Barbieri S., Sonvico F., Colombo P., Natali F., Deriu A (literal)

Pagina inizio

• 685 (literal)

Pagina fine

• 691 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 6 (literal)

Rivista

• Soft matter (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• aDipartimento di Fisica, Universit?a degli Studi di Parma, CNISM, INFM-CNR and CRS-SOFT, Parma, Italy. E-mail: Yuri.Gerelli@fis. unipr.it bDipartimento Farmaceutico, Universit?a degli Studi di Parma, Parma, Italy cINFM-CNR and CRS-SOFT, Operative Group in Grenoble, France (literal)

Titolo

• Flexibility and drug release features of lipid/saccharide nanoparticles (literal)

Abstract

• The effect of lipophilic additives (excipients and drugs) on the behavior of lipid/saccharide nanoparticles has been investigated by incoherent elastic neutron scattering. Temperature scans from 20 K to 350 K have been performed on lecithin/chitosan particles loaded with isopropyl myristate and cetyl-stearyl alcohol, two lipophilic molecules with different melting temperatures which are commonly added to improve drug loading efficiency. In a similar way the effect of tamoxifen citrate, a lipophilic drug frequently used in breast cancer therapy, has also been studied. The different melting points of the two excipients affect mostly the low-temperature behavior of the nanoparticles. At physiological temperatures they both improve the particle flexibility. On the other hand addition of tamoxifen leads to stiffer structures and to lower amounts of released drug. The macroscopic features of the drug release appear to be correlated to the microscopic flexibility determined by neutron scattering. The data confirm also the role of chitosan as a stiffening and stabilizing agent of the lipid particles. (literal)

Prodotto di

• MD.P06.014.001 Teoria e modeling computazionale di materiali e processi per le nanoscienze (MD.P06.014.002) (Modulo)

Autore CNR

• FRANCESCA NATALI (Persona)
• LUCIANO COLOMBO (Persona)

Incoming links:

Autore CNR di

• FRANCESCA NATALI (Persona)
• LUCIANO COLOMBO (Persona)

Prodotto

• MD.P06.014.001 Teoria e modeling computazionale di materiali e processi per le nanoscienze (MD.P06.014.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Soft matter (Rivista)