http://www.cnr.it/ontology/cnr/individuo/prodotto/ID57605
Unfolding times for proteins in a force clamp (Articolo in rivista)
- Type
- Label
- Unfolding times for proteins in a force clamp (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1103/PhysRevE.81.010902 (literal)
- Alternative label
Luccioli S. (1,2); Imparato A. (3); Mitternacht S. (4,5); Irbäck A. (4); Torcini A. (1,2); (2010)
Unfolding times for proteins in a force clamp
in Physical review. E, Statistical, nonlinear, and soft matter physics (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Luccioli S. (1,2); Imparato A. (3); Mitternacht S. (4,5); Irbäck A. (4); Torcini A. (1,2); (literal)
- Pagina inizio
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- p. 010902(R). American Physical Society. (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1) Istituto dei Sistemi Complessi, CNR, via Madonna del Piano 10, I-50019 Sesto Fiorentino, Italy
2) INFN, Sez. Firenze, CSDC, via Sansone, 1-I-50019 Sesto Fiorentino, Italy
3) Department of Physics and Astronomy, University of Aarhus, Ny Munkegade, Building 1520, DK-8000 Aarhus C, Denmark
4) Department of Theoretical Physics, Lund University, Sölvegatan 14A, SE-223 62 Lund, Sweden
5) Department of Informatics, University of Bergen, PB 7803, N-5020 Bergen, Norway (literal)
- Titolo
- Unfolding times for proteins in a force clamp (literal)
- Abstract
- The escape process from the native valley for proteins subjected to a constant stretching force is examined
using a model for a ? barrel. For a wide range of forces, the unfolding dynamics can be treated as onedimensional
diffusion, parametrized in terms of the end-to-end distance. In particular, the escape times can be
evaluated as first passage times for a Brownian particle moving on the protein free-energy landscape, using the
Smoluchowski equation. At strong forces, the unfolding process can be viewed as a diffusive drift away from
the native state, while at weak forces thermal activation is the relevant mechanism. An escape-time analysis
within this approach reveals a crossover from an exponential to an inverse Gaussian escape-time distribution
upon passing from weak to strong forces. Moreover, a single expression valid at weak and strong forces can be
devised both for the average unfolding time as well as for the corresponding variance. The analysis offers a
possible explanation of recent experimental findings for the proteins ddFLN4 and ubiquitin. (literal)
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