Unfolding times for proteins in a force clamp (Articolo in rivista)

Type
Label
  • Unfolding times for proteins in a force clamp (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1103/PhysRevE.81.010902 (literal)
Alternative label
  • Luccioli S. (1,2); Imparato A. (3); Mitternacht S. (4,5); Irbäck A. (4); Torcini A. (1,2); (2010)
    Unfolding times for proteins in a force clamp
    in Physical review. E, Statistical, nonlinear, and soft matter physics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Luccioli S. (1,2); Imparato A. (3); Mitternacht S. (4,5); Irbäck A. (4); Torcini A. (1,2); (literal)
Pagina inizio
  • 010902(R) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 81 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • p. 010902(R). American Physical Society. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1) Istituto dei Sistemi Complessi, CNR, via Madonna del Piano 10, I-50019 Sesto Fiorentino, Italy 2) INFN, Sez. Firenze, CSDC, via Sansone, 1-I-50019 Sesto Fiorentino, Italy 3) Department of Physics and Astronomy, University of Aarhus, Ny Munkegade, Building 1520, DK-8000 Aarhus C, Denmark 4) Department of Theoretical Physics, Lund University, Sölvegatan 14A, SE-223 62 Lund, Sweden 5) Department of Informatics, University of Bergen, PB 7803, N-5020 Bergen, Norway (literal)
Titolo
  • Unfolding times for proteins in a force clamp (literal)
Abstract
  • The escape process from the native valley for proteins subjected to a constant stretching force is examined using a model for a ? barrel. For a wide range of forces, the unfolding dynamics can be treated as onedimensional diffusion, parametrized in terms of the end-to-end distance. In particular, the escape times can be evaluated as first passage times for a Brownian particle moving on the protein free-energy landscape, using the Smoluchowski equation. At strong forces, the unfolding process can be viewed as a diffusive drift away from the native state, while at weak forces thermal activation is the relevant mechanism. An escape-time analysis within this approach reveals a crossover from an exponential to an inverse Gaussian escape-time distribution upon passing from weak to strong forces. Moreover, a single expression valid at weak and strong forces can be devised both for the average unfolding time as well as for the corresponding variance. The analysis offers a possible explanation of recent experimental findings for the proteins ddFLN4 and ubiquitin. (literal)
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