http://www.cnr.it/ontology/cnr/individuo/prodotto/ID57589

Rate maintenance and resonance in the entorhinal cortex (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Rate maintenance and resonance in the entorhinal cortex (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1111/j.1460-9568.2010.07455.x (literal)

Alternative label

Haas J.S.; Kreuz T.; Torcini A.; Politi A.; Abarbanel H.D.I. (2010)
Rate maintenance and resonance in the entorhinal cortex
in European journal of neuroscience (Print)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Haas J.S.; Kreuz T.; Torcini A.; Politi A.; Abarbanel H.D.I. (literal)

Pagina inizio

1930 (literal)

Pagina fine

1939 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

32 (literal)

Rivista

European journal of neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

fasc. (11). Federation of European Neuroscience Societies and Blackwell Publishing Ltd ; Wiley (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Institute for Nonlinear Science (INLS), University of California San Diego (UCSD), La Jolla, CA, USA, Institute for Nonlinear Science (INLS), University of California San Diego (UCSD), La Jolla, CA, USA and CNR-ISC Firenze, Sesto Fiorentino, CNR-ISC Firenze, Sesto Fiorentino and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Sesto Fiorentino, Italy and Centro Studi Dinamiche Complesse (CSDC), Sesto Fiorentino, Italy, CNR-ISC Firenze, Sesto Fiorentino and Centro Studi Dinamiche Complesse (CSDC), Sesto Fiorentino, Italy, Institute for Nonlinear Science (INLS), Univ. of California San Diego (UCSD), La Jolla, CA, USA and Dept. of Physics, Univ. of California San Diego, La Jolla, CA, USA and Marine Physical Laboratory (Scripps Institution of Oceanography), Univ. of Californi (literal)

Titolo

Rate maintenance and resonance in the entorhinal cortex (literal)

Abstract

Throughout the brain, neurons encode information in fundamental units of spikes. Each spike represents the combined thresholding of synaptic inputs and intrinsic neuronal dynamics. Here, we address a basic question of spike train formation - how do perithreshold synaptic inputs perturb the output of a spiking neuron? We recorded from single entorhinal principal cells in vitro and drove them to spike steadily at ?5 Hz (theta range) with direct current injection, then used a dynamic-clamp to superimpose strong excitatory conductance inputs at varying rates. Neurons spiked most reliably when the input rate matched the intrinsic neuronal firing rate. We also found a striking tendency of neurons to preserve their rates and coefficients of variation, independently of input rates. As mechanisms for this rate maintenance, we show that the efficacy of the conductance inputs varied with the relationship of input rate to neuronal firing rate, and with the arrival time of the input within the natural period. Using a novel method of spike classification, we developed a minimal Markov model that reproduced the measured statistics of the output spike trains and thus allowed us to identify and compare contributions to the rate maintenance and resonance. We suggest that strength of rate maintenance may be used as a new categorization scheme for neuronal response and note that individual intrinsic spiking mechanisms may play a significant role in forming the rhythmic spike trains of activated neurons; in the entorhinal cortex, individual pacemakers may dominate production of the regional theta rhythm. (literal)

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