Cucumber mosaic virus as the expression system for a potential vaccine against Alzheimer's disease (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Cucumber mosaic virus as the expression system for a potential vaccine against Alzheimer's disease (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jviromet.2010.07.039 (literal)

Alternative label

• Vitti A.1, Piazzolla G. 2, Condelli V.1, Nuzzaci M.1,Lanorte M.T. 1, Boscia D., De Stradis A., Antonaci S.2, Piazzolla P.1, Tortorella C.2 (2010)
  Cucumber mosaic virus as the expression system for a potential vaccine against Alzheimer's disease
  in Journal of virological methods
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vitti A.1, Piazzolla G. 2, Condelli V.1, Nuzzaci M.1,Lanorte M.T. 1, Boscia D., De Stradis A., Antonaci S.2, Piazzolla P.1, Tortorella C.2 (literal)

Pagina inizio

• 332 (literal)

Pagina fine

• 340 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 169 (literal)

Rivista

• Journal of virological methods (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Note

• PubMe (literal)
• Scopus (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IVV - UOS BARI 1) Dipartimento di biologia, protezione delle piante e agrobiotecnologie, Università della Basilicata, viale dell’Ateneo Lucano, 10, 85100, Potenza, Italy 2) Dipartimento di Medicina Interna, immunologia e Malattie Infettive, Sezione di Medicina Interna, Università di Bari, 70124, Bari, Italy (literal)

Titolo

• Cucumber mosaic virus as the expression system for a potential vaccine against Alzheimer's disease (literal)

Abstract

• A primary therapeutic goal in Alzheimer’s disease (AD) is to reduce the quantity of amyloid b protein (A b) present in the brain. To develop an effective, safe system for vaccination against Alzheimer’s disease, the plant virus Cucumber mosaic virus (CMV) was engineered genetically to express A b -derived fragments that stimulate mainly humoral immune responses. Six chimeric constructs, bearing the A b 1–15 or the A b 4–15 sequence in positions 248, 392 or 529 of the CMV coat protein (CP) gene, were created. Viral products proved to be able to replicate in their natural host. However, only chimeric A b 1–15-CMVs were detected by A b 1–42 antiserum in Western blot analysis. Experimental evidence of Immunoelectron microscopy revealed a complete decoration of A b 1–15-CMV248 and A b 1–5-CMV392 following incubation with either anti-A b 1–15 or anti-A b 1–42 polyclonal antibodies. These two chimeric CMVs appear to be endowed with features making them possible candidates for vaccination against Alzheimer’s disease. (literal)

Prodotto di

• Interazioni biologiche e molecolari delle piante con virus e agenti patogeni virus-simili (AG.P01.010.001) (Modulo)

Autore CNR

• ANGELO DE STRADIS (Unità di personale interno)
• DONATO BOSCIA (Persona)

Insieme di parole chiave

• Parole chiave di "Cucumber mosaic virus as the expression system for a potential vaccine against Alzheimer's disease" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANGELO DE STRADIS (Unità di personale interno)
• DONATO BOSCIA (Persona)

Prodotto

• Interazioni biologiche e molecolari delle piante con virus e agenti patogeni virus-simili (AG.P01.010.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of virological methods (Rivista)

Insieme di parole chiave di

• Parole chiave di "Cucumber mosaic virus as the expression system for a potential vaccine against Alzheimer's disease" (Insieme di parole chiave)