Structural and biological properties of Cucumber mosaic virus particles carrying hepatitis C virus-derived epitopes. (Articolo in rivista)

Type
Label
  • Structural and biological properties of Cucumber mosaic virus particles carrying hepatitis C virus-derived epitopes. (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jviromet.2008.10.005 (literal)
Alternative label
  • M. Nuzzaci1; I. Bochicchio2; A. DE STRADIS; A Vitti1; A. Natilla1; P. Piazzolla1; A.M. Tamburro2; (2009)
    Structural and biological properties of Cucumber mosaic virus particles carrying hepatitis C virus-derived epitopes.
    in Journal of virological methods
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M. Nuzzaci1; I. Bochicchio2; A. DE STRADIS; A Vitti1; A. Natilla1; P. Piazzolla1; A.M. Tamburro2; (literal)
Pagina inizio
  • 118 (literal)
Pagina fine
  • 121 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 155 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • IMPACT FACTOR 2008: 2.077 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopus (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • AFFILIAZIONE AUTORI (Enti di appartenenza degli autori non CNR): 1) Dipartimento di Biologia, Protezione delle Piante ed Agrobiotecnologia -Università della Basilicata-Potenza; 2) Dipartimento di Chimica-Università della Basilicata-Potenza; (literal)
Titolo
  • Structural and biological properties of Cucumber mosaic virus particles carrying hepatitis C virus-derived epitopes. (literal)
Abstract
  • ABSTRACT: The Cucumber mosaic virus (CMV) is a three-component isodiametric plant virus with an extremely wide host range, present worldwide. A pseudorecombinant form has been described, deriving from the RNA3 component of CMV-S strain, carrying the coat protein (CP) gene, and the RNA 1, 2 components of the CMV-D strain. The CP gene was then engineered to express one or two copies of a synthetic peptide derived from many hypervariable region 1 (HVR1) sequences of the Hepatitis C virus (HCV) envelope protein E2 (the so-called R9 mimotope). Study of symptoms pattern displayed in tobacco by these chimeric CMV particles, together with determination of their structural characteristics, assessed by circular dchroism (CD) spectroscopy and electron microscopy, revealed a possible relationship between the biological behavior and the structural properties of viru components. (literal)
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