http://www.cnr.it/ontology/cnr/individuo/prodotto/ID56159
The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide (Articolo in rivista)
- Type
- Label
- The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bbabio.2011.08.007 (literal)
- Alternative label
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- Zulian A; Sileikyte J; Petronilli V; Bova S; Dabbeni-Sala F; Cargnelli G; Rennison D; Brimble MA; Hopkins B; Bernardi P; Ricchelli F. (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Zulian A, Sileikyte J, Bova S, Dabbeni-Sala F, Cargnelli G, University of Padova
Rennison D, Brimble MA, Hopkins B, University of Auckland,New Zealand;Canterbury Agriculture and Science Centre, Lincoln, New Zealand
Petronilli V,Bernardi P, Ricchelli F., CNR (literal)
- Titolo
- The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide (literal)
- Abstract
- We have investigated the mechanism of rat-selective induction of the mitochondrial permeability transition
(PT) by norbormide (NRB). We show that the inducing effect of NRB on the PT (i) is inhibited by the selective
ligands of the 18 kDa outer membrane (OMM) translocator protein (TSPO, formerly peripheral benzodiazepine
receptor) protoporphyrin IX, N,N-dihexyl-2-(4-fluorophenyl)indole-3-acetamide and 7-chloro-5-(4-
chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one; and (ii) is lost in digitonin mitoplasts,
which lack an intact OMM. In mitoplasts the PT can still be induced by the NRB cationic derivative OL14,
which contrary to NRB is also effective in intact mitochondria from mouse and guinea pig. We conclude
that selective NRB transport into rat mitochondria occurs via TSPO in the OMM, which allows its translocation
to PT-regulating sites in the inner membrane. Thus, species-specificity of NRB toward the rat PT depends on
subtle differences in the structure of TSPO or of TSPO-associated proteins affecting its substrate specificity (literal)
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