http://www.cnr.it/ontology/cnr/individuo/prodotto/ID56134
The immunostimulatory effect of IL-1 beta in vivo is blocked by antisense peptides complementary to the loop sequence 163-171 (Articolo in rivista)
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- The immunostimulatory effect of IL-1 beta in vivo is blocked by antisense peptides complementary to the loop sequence 163-171 (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
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- Boraschi D., Tagliabue A., Miller A.D. (literal)
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- Diana Boraschi (Unit of Immunobiology, Inst. Of Biomedical Technologies, CNR, Pisa), Aldo Tagliabue (ALTA Srl, Siena), Andrew D. Miller (Imperial College Genetic Therapies Centre, Dept. Of Chemistry, Imperial College London, UK) (literal)
- Titolo
- The immunostimulatory effect of IL-1 beta in vivo is blocked by antisense peptides complementary to the loop sequence 163-171 (literal)
- Abstract
- Antisense (AS) peptides complementary to the b-bulge surface loop VQGEESNDK (Boraschi loop) of the
cytokine interleukin-1b (IL-1b) have been shown to bind IL-1b at the Boraschi loop position, and to
inhibit some of the IL-1b-mediated biological effects in vitro. Here we show that primary AS peptide
FVITFFSLY inhibits IL-1b-mediated immunostimulation in vivo in a dose-dependent fashion, while
inactive on IL-1b-induced inflammation, an effect that takes place independently of the Boraschi loop.
To the best of our knowledge, this is the first time that an AS peptide has been used successfully in vivo.
? 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. (literal)
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