http://www.cnr.it/ontology/cnr/individuo/prodotto/ID56089
The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events. (Articolo in rivista)
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- Label
- The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events. (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.3109/17435390903374001 (literal)
- Alternative label
Pfaller, T., R. Colognato, I. Nelissen, F. Favilli, E. Casals, D. Ooms, H. Leppens, J. Ponti, R. Stritzinger, V. F. Puntes, D. Boraschi, A. Duschl, and G. J. Oostingh (2010)
The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events.
in Nanotoxicology (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pfaller, T., R. Colognato, I. Nelissen, F. Favilli, E. Casals, D. Ooms, H. Leppens, J. Ponti, R. Stritzinger, V. F. Puntes, D. Boraschi, A. Duschl, and G. J. Oostingh (literal)
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- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Pfaller, Stritzinger, Duschl, Oostingh: Department of Molecular Biology, University of Salzburg, Austria
Colognato, Ponti: European Commission, Joint Research Centre, Institute for Health and Consumer Protection, NanoBioSciences Unit, Ispra, Italy
Nelissen, Ooms, Leppens: Flemish Institute for Technological Research (VITO NV), Environmental Risk and Health Unit, Mol, Belgium
Boraschi, Favilli: Institute of Biomedical Technologies, National Research Council, Pisa, Italy
Casals, Puntes: Institut Català de Nanotecnologia (CIN2-ICN) and Institut Català de Recerca I Estudis Avançats (ICREA), Barcelona, Spain (literal)
- Titolo
- The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events. (literal)
- Abstract
- Suitable assays and test strategies are needed to analyze potential genotoxic and immunotoxic health effects caused by
nanoparticle exposure. The development and validation of such methods is challenging because nanoparticles may show
unexpected behavior, like aggregation or interference with optical measurements, when routine in vitro assays are performed.
In our interdisciplinary study, the effects of inorganic gold (4.5 nm) and iron oxide (7.3 nm) nanoparticles with a narrow size
distribution were tested on human cells using different assay systems. The results show that cytotoxicity as well as
immunotoxicity and genotoxicity induced by these two inorganic nanoparticles was low or absent when using a panel of
cell-based tests in different laboratories. However, several technical issues had to be tackled that were specific for working with
nanoparticles. The methods used, their suitability for nanotoxicity testing, and the technical problems encountered are
carefully described and discussed in this paper. (literal)
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