http://www.cnr.it/ontology/cnr/individuo/prodotto/ID56084
UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs (Articolo in rivista)
- Type
- Label
- UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1093/nar/gkp902 (literal)
- Alternative label
Giorgio Grillo 1; Antonio Turi 2; Flavio Licciulli 1; Flavio Mignone 3; Sabino Liuni 1; Sandro Banfi 4; Vincenzo Alessandro Gennarino 4; David S. Horner 5; Giulio Pavesi 5; Ernesto Picardi 2; Graziano Pesole 1,2 (2010)
UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs
in Nucleic acids research
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Giorgio Grillo 1; Antonio Turi 2; Flavio Licciulli 1; Flavio Mignone 3; Sabino Liuni 1; Sandro Banfi 4; Vincenzo Alessandro Gennarino 4; David S. Horner 5; Giulio Pavesi 5; Ernesto Picardi 2; Graziano Pesole 1,2 (literal)
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- 1 Istituto Tecnologie Biomediche del Consiglio Nazionale delle Ricerche (CNR), via Amendola 122/D, 70126 Bari,
2 Dipartimento di Biochimica e Biologia Molecolare 'E. Quagliariello', Universita` di Bari, via Orabona 4, 70126 Bari,
3 Dipartimento di Chimica Strutturale e Stereochimica Inorganica, Universita` degli Studi di Milano, 20133 Milano,
4 Telethon Institute of Genetics and Medicine, via Pietro Castellino 111, 80131 Naples
5 Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita` di Milano, via Celoria 26, 20133 Milano, Italy (literal)
- Titolo
- UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs (literal)
- Abstract
- The 5' and 3' untranslated regions of eukaryotic mRNAs (UTRs) play crucial roles in the post-trans-criptional regulation of gene expression through the modulation of nucleo-cytoplasmic mRNA transport, translation efficiency, subcellular localization and message stability. UTRdb is a curated database of 5' and 3' untranslated sequences of eukaryotic mRNAs, derived from several sources of primary data. Experimentally validated functional motifs are annotated and also collated as the UTRsite database where more specific information on the functional motifs and cross-links to interacting regulatory protein are provided. In the current update, the UTR entries have been organized in a gene-centric structure to better visualize and retrieve 5' and 3' UTR variants generated by alter-native initiation and termination of transcription and alternative splicing. Experimentally validated miRNA targets and conserved sequence elements are also annotated. The integration of UTRdb with genomic data has allowed the implementation of an efficient annotation system and a powerful retrieval resource for the selection and extraction of specific UTR subsets. All internet resources implemented for retrieval and functional analysis of 5' and 3' untranslated regions of eukaryotic mRNAs are accessible at http://utrdb.ba.itb.cnr.it/. (literal)
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