Metabolism of borono-phenylalanine-fructose complex (BPA-fr) and borocaptate sodium (BSH) in cancer patients--results from EORTC trial 11001. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Metabolism of borono-phenylalanine-fructose complex (BPA-fr) and borocaptate sodium (BSH) in cancer patients--results from EORTC trial 11001. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jpba.2009.08.018 (literal)

Alternative label

• Bendel P, Wittig A, Basilico F, Mauri PL, Sauerwein W. (2010)
  Metabolism of borono-phenylalanine-fructose complex (BPA-fr) and borocaptate sodium (BSH) in cancer patients--results from EORTC trial 11001.
  in Journal of pharmaceutical and biomedical analysis (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bendel P, Wittig A, Basilico F, Mauri PL, Sauerwein W. (literal)

Pagina inizio

• 284 (literal)

Pagina fine

• 287 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 51 (literal)

Rivista

• Journal of pharmaceutical and biomedical analysis (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Weizmann Inst Sci, Dept Chem Res Support, IL-76100 Rehovot, Israel 2. Univ Duisburg Essen, Univ Hosp Essen, Dept Radiat Oncol, D-45122 Essen, Germany 3. Inst Biomed Technol, Prote & Metab Unit, Milan, Italy (literal)

Titolo

• Metabolism of borono-phenylalanine-fructose complex (BPA-fr) and borocaptate sodium (BSH) in cancer patients--results from EORTC trial 11001. (literal)

Abstract

• Within the clinical trial EORTC 11001, patients were infused with (11)B-enriched borono-phenylalanine-fructose complex (BPA-fr), or borocaptate sodium (BSH) solutions, which are used as boron carriers for boron neutron capture therapy. Urine samples were periodically collected and analyzed by (10)B NMR spectroscopy. The results revealed time-dependent metabolic changes of the administered compounds. BPA-fr dissociated to the constituents BPA and fructose, and the borate group was partly cleaved from BPA. BSH was partly aggregated to a dimer form, BSSB. These observations were previously reported for cultured cells and animal models, and are confirmed here in human cancer patients. (literal)

Prodotto di

• ProteoMetabolomica - Sviluppo ed applicazione della LC-MS/MS per lo studio di proteine e metaboliti (PM.P06.008.003) (Modulo)

Autore CNR

• PIETRO LUIGI MAURI (Persona)
• FABRIZIO BASILICO (Unità di personale interno)

Incoming links:

Autore CNR di

• PIETRO LUIGI MAURI (Persona)
• FABRIZIO BASILICO (Unità di personale interno)

Prodotto

• ProteoMetabolomica - Sviluppo ed applicazione della LC-MS/MS per lo studio di proteine e metaboliti (PM.P06.008.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of pharmaceutical and biomedical analysis (Rivista)