Serum and urinary levels of IL-18 and its inhibitor IL-18BP in Systemic Lupus Erythematosus (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Serum and urinary levels of IL-18 and its inhibitor IL-18BP in Systemic Lupus Erythematosus (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Migliorini, P., C. Anzilotti, F. Pratesi, P. Quattroni, M. Bargagna, C.A. Dinarello, and D. Boraschi (2010)
  Serum and urinary levels of IL-18 and its inhibitor IL-18BP in Systemic Lupus Erythematosus
  in European cytokine network (Montrouge)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Migliorini, P., C. Anzilotti, F. Pratesi, P. Quattroni, M. Bargagna, C.A. Dinarello, and D. Boraschi (literal)

Pagina inizio

• 264 (literal)

Pagina fine

• 271 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• European cytokine network (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Migliorini, Anzilotti, Pratesi: Clinical Immunology Unit, Department of Internal Medicine, University of Pisa, Pisa, Italy Quattroni, Bargagna, Boraschi: Immunobiology Unit, Institute of Biomedical Technologies, National Research Council, Pisa, Italy Dinarello: Dept. Infectious Diseases, University of Colorado Medical School, Denver, CO, USA (literal)

Titolo

• Serum and urinary levels of IL-18 and its inhibitor IL-18BP in Systemic Lupus Erythematosus (literal)

Abstract

• Overproduction of inflammation-related cytokines plays an important role in systemic lupus erythematosus (SLE). A crucial cytokine is IL-18, a member of the IL-1 family involved in the regulation of both innate and acquired immune responses. The aim of this study was to evaluate free IL-18 levels in the serum and urine of SLE patients, in order to establish their relationship with other biomarkers of disease activity. Serum and urine levels of IL-18 and IL-18BP were measured by ELISA in 50 SLE patients and in 32 healthy subjects; free IL-18 was calculated using the law of mass action. Serum levels of total IL-18, IL-18BP and free IL-18 were higher in SLE patients than in healthy controls. Total and free serum IL-18 levels were higher in patients with active disease (with nephritis or active non-renal disease), and correlated with the ECLAM score. Urinary levels of total and free IL-18 were higher in patients than in controls, but did not correlate with disease activity. The data collected in this study show that increased levels of both IL-18 and its natural inhibitor IL-18BP, characterise SLE. Despite the overproduction of IL-18BP, free IL-18 is still significantly higher in SLE patients than in controls, and its serum levels are a marker of disease activity. (literal)

Prodotto di

• Immunità innata: ruolo di difesa e alterazioni patologiche (ME.P03.010.004) (Modulo)

Autore CNR

• DIANA BORASCHI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Serum and urinary levels of IL-18 and its inhibitor IL-18BP in Systemic Lupus Erythematosus" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DIANA BORASCHI (Unità di personale interno)

Prodotto

• Immunità innata: ruolo di difesa e alterazioni patologiche (ME.P03.010.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European cytokine network (Rivista)

Insieme di parole chiave di

• Parole chiave di "Serum and urinary levels of IL-18 and its inhibitor IL-18BP in Systemic Lupus Erythematosus" (Insieme di parole chiave)