http://www.cnr.it/ontology/cnr/individuo/prodotto/ID56018
Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration. (Articolo in rivista)
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- Label
- Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration. (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.ejphar.2008.08.020 (literal)
- Alternative label
Marchese G a,b; Sanna A b; Casu G b; Casti P b; Spada GP b; Ruiu S a,b; Pani L a,b (2008)
Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration.
in European journal of pharmacology; Editore: Elsevier, Oxford (Regno Unito)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Marchese G a,b; Sanna A b; Casu G b; Casti P b; Spada GP b; Ruiu S a,b; Pani L a,b (literal)
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- http://www.elsevier.com/locate/ejphar (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- a C.N.R., Institute of Biomedical Technology, Sect. Cagliari, Technological Park of Sardinia\"Sardegna Ricerche\", Pula, Cagliari, Italy
b Neuroscienze-Pharmaness S.c.a r.l., Technological Park of Sardinia\"Sardegna Ricerche\", Pula, Cagliari, Italy (literal)
- Titolo
- Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration. (literal)
- Abstract
- It was previously shown that haloperidol, but not clozapine, induced intense rat
catalepsy when co-administered with delta-9-tetrahydrocannabinol. The present
study investigated whether similar alterations could be observed on striatal
c-Fos immunoreactivity after administration of the same drug combinations.
Western Blot and immunocytochemistry stereological analyses indicated that
delta-9-tetrahydrocannabinol (0.5 mg/kg) increased striatal c-Fos
immunoreactivity induced by haloperidol (0.1 mg/kg). Conversely, no significant
alterations of striatal c-Fos immunoreactivity were observed after injections of
clozapine (10 mg/kg)+vehicle, clozapine+delta-9-tetrahydrocannabinol or
vehicle+delta-9-tetrahydrocannabinol. The present results indicate that the
behavioral effects induced by delta-9-tetrahydrocannabinol in haloperidol- and
clozapine-treated rats are associated with different striatal c-Fos expressions. (literal)
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