Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration. (Articolo in rivista)

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  • Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ejphar.2008.08.020 (literal)
Alternative label
  • Marchese G a,b; Sanna A b; Casu G b; Casti P b; Spada GP b; Ruiu S a,b; Pani L a,b (2008)
    Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration.
    in European journal of pharmacology; Editore: Elsevier, Oxford (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Marchese G a,b; Sanna A b; Casu G b; Casti P b; Spada GP b; Ruiu S a,b; Pani L a,b (literal)
Pagina inizio
  • 16 (literal)
Pagina fine
  • 20 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.elsevier.com/locate/ejphar (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 598 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1-3 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a C.N.R., Institute of Biomedical Technology, Sect. Cagliari, Technological Park of Sardinia\"Sardegna Ricerche\", Pula, Cagliari, Italy b Neuroscienze-Pharmaness S.c.a r.l., Technological Park of Sardinia\"Sardegna Ricerche\", Pula, Cagliari, Italy (literal)
Titolo
  • Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration. (literal)
Abstract
  • It was previously shown that haloperidol, but not clozapine, induced intense rat catalepsy when co-administered with delta-9-tetrahydrocannabinol. The present study investigated whether similar alterations could be observed on striatal c-Fos immunoreactivity after administration of the same drug combinations. Western Blot and immunocytochemistry stereological analyses indicated that delta-9-tetrahydrocannabinol (0.5 mg/kg) increased striatal c-Fos immunoreactivity induced by haloperidol (0.1 mg/kg). Conversely, no significant alterations of striatal c-Fos immunoreactivity were observed after injections of clozapine (10 mg/kg)+vehicle, clozapine+delta-9-tetrahydrocannabinol or vehicle+delta-9-tetrahydrocannabinol. The present results indicate that the behavioral effects induced by delta-9-tetrahydrocannabinol in haloperidol- and clozapine-treated rats are associated with different striatal c-Fos expressions. (literal)
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