Manganese intoxication decreases the expression of manganoproteins in the rat basal ganglia: an immunohistochemical study. (Articolo in rivista)

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  • Manganese intoxication decreases the expression of manganoproteins in the rat basal ganglia: an immunohistochemical study. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Morello M, Zatta P, Zambenedetti P, Martorana A, D'Angelo V, Melchiorri G, Bernardi G, Sancesario G (2007)
    Manganese intoxication decreases the expression of manganoproteins in the rat basal ganglia: an immunohistochemical study.
    in Brain research bulletin
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Morello M, Zatta P, Zambenedetti P, Martorana A, D'Angelo V, Melchiorri G, Bernardi G, Sancesario G (literal)
Pagina inizio
  • 406 (literal)
Pagina fine
  • 415 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 74 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istitute for Biomedical Technologies-CNR- Padua Section Department of Neuroscience, University of Rome Tor Vergata, Rome (literal)
Titolo
  • Manganese intoxication decreases the expression of manganoproteins in the rat basal ganglia: an immunohistochemical study. (literal)
Abstract
  • Manganese (Mn) is a cofactor for some metalloprotein enzymes, including Mn-superoxide dismutase (Mn-SOD), a mitochondrial enzyme predominantly localized in neurons, and glutamine synthetase (GS), which is selectively expressed in astroglial cells. The detoxifying effects of GS and Mn-SOD in the brain, involve catabolizing glutamate and scavenging superoxide anions, respectively. Mn intoxication is characterized by impaired function of the basal ganglia. However, it is unclear whether regional central nervous system expression of manganoproteins is also affected. Here, we use immunocytochemistry in the adult rat brain, to examine whether Mn overload selectively affects the expression of GS, Mn-SOD, Cu/Zn-SOD, another component of the SOD family, and glial fibrillary acid protein (GFAP), a specific marker of astrocytes. After chronic Mn overload in drinking water for 13 weeks, we found that the number and immunostaining intensity of GS- and Mn-SOD-positive cells was significantly decreased in the striatum and globus pallidus, but not in the cerebral frontal cortex. (literal)
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