ProCMD: a database and 3D web resource for protein C mutants. (Articolo in rivista)

Type
Label
  • ProCMD: a database and 3D web resource for protein C mutants. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1186/1471-2105-8-S1-S11 (literal)
Alternative label
  • D'Ursi P, Marino F, Caprera A, Milanesi L, Faioni EM, Rovida E. (2007)
    ProCMD: a database and 3D web resource for protein C mutants.
    in BMC bioinformatics
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • D'Ursi P, Marino F, Caprera A, Milanesi L, Faioni EM, Rovida E. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 8 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Department of Science and Biomedical Technologies, University of Milano, Italy 2Institute of Biomedical Technologies, National Research Council, Segrate (Mi), Italy 3Hematology and Thrombosis Unit, DMCO- University of Milano and Az. Ospedaliera San Paolo, Italy (literal)
Titolo
  • ProCMD: a database and 3D web resource for protein C mutants. (literal)
Abstract
  • Activated Protein C (ProC) is an anticoagulant plasma serine protease which also plays an important role in controlling inflammation and cell proliferation. Several mutations of the gene are associated with phenotypic functional deficiency of protein C, and with the risk of developing venous thrombosis. Structure prediction and computational analysis of the mutants have proven to be a valuable aid in understanding the molecular aspects of clinical thrombophilia. We have built a specialized relational database and a search tool for natural mutants of protein C. It contains 195 entries that include 182 missense and 13 stop mutations. A menu driven search engine allows the user to retrieve stored information for each variant, that include genetic as well as structural data and a multiple alignment highlighting the substituted position. Molecular models of variants can be visualized with interactive tools; PDB coordinates of the models are also available for further analysis. Furthermore, an automatic modelling interface allows the user to generate multiple alignments and 3D models of new variants. ProCMD is an up-to-date interactive mutant database that (literal)
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