LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts. Correlation with pharmacological activity (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts. Correlation with pharmacological activity (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jpba.2005.10.048 (literal)

Alternative label

• P.L. Mauri; A. De Palma; F. Pozzi; F. Basilico; A. Riva; P.Morazzoni; E.Bombardelli; G. Rossoni. (2006)
  LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts. Correlation with pharmacological activity
  in Journal of pharmaceutical and biomedical analysis (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• P.L. Mauri; A. De Palma; F. Pozzi; F. Basilico; A. Riva; P.Morazzoni; E.Bombardelli; G. Rossoni. (literal)

Pagina inizio

• 763 (literal)

Pagina fine

• 768 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 40 (literal)

Rivista

• Journal of pharmaceutical and biomedical analysis (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto Tecnologie Biomediche Università di Milano Indena S.p.A (literal)

Titolo

• LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts. Correlation with pharmacological activity (literal)

Abstract

• Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry (LC/APCI-ITMS) was applied to determine the concentration of terpene lactone in plasma of guinea pigs after chronic administration of Ginkgo biloba extract enriched in ginkgoterpenes in free form (IDN 5380) or complexed with soy phosphlipids (IDN 5381). Oral treatment of the animals with ginkgoterpenes resulted to inhibit the bronchoconstriction (ITP) and the concomitant increase of the levels of thromboxane B-2 (TXB2) in the circulation caused by histamine (HIST) and platelet activating factor (PAF) in normal guinea pigs or by ovalbumin (OA) in actively sensitized guinea pigs. To compare the protective activities of G. biloba forms (IDN 5380 and IDN 5381), ED50 and dose ratio (DR) values for both parameters (ITP and TXB2) were evaluated. The phytosomic form (IDN 5381) significantly reduced (two- to four-fold as compared to free form, P < 0.001) the HIST, PAF or OA-induced airway changes and TXB2 release. In addition it has been observed that the absence of ginkgolide C (GC) in plasma samples (in human and animals) was due to its rapid methylation. (c) 2005 Elsevier B.V. All rights reserved. (literal)

Prodotto di

• ProteoMetabolomica - Sviluppo ed applicazione della LC-MS/MS per lo studio di proteine e metaboliti (PM.P06.008.003) (Modulo)

Autore CNR

• FABRIZIO BASILICO (Persona)
• PIETRO LUIGI MAURI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts. Correlation with pharmacological activity" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• PIETRO LUIGI MAURI (Unità di personale interno)
• FABRIZIO BASILICO (Persona)

Prodotto

• ProteoMetabolomica - Sviluppo ed applicazione della LC-MS/MS per lo studio di proteine e metaboliti (PM.P06.008.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of pharmaceutical and biomedical analysis (Rivista)

Insieme di parole chiave di

• Parole chiave di "LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts. Correlation with pharmacological activity" (Insieme di parole chiave)