http://www.cnr.it/ontology/cnr/individuo/prodotto/ID55830
MitoRes: a resource of nuclear-encoded mitochondrial genes and their products in Metazoa (Articolo in rivista)
- Type
- Label
- MitoRes: a resource of nuclear-encoded mitochondrial genes and their products in Metazoa (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1186/1471-2105-7-36 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Domenico Catalano 1; Flavio Licciulli 1; Antonio Turi 1; Giorgio Grillo 1;
Cecilia Saccone 1,2; and Domenica D'Elia 1; (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1 Institute of Biomedical Technologies, CNR, Via Amendola 122/D, 70126 Bari, Italy;
2 Department of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70126 Bari, Italy; (literal)
- Titolo
- MitoRes: a resource of nuclear-encoded mitochondrial genes and their products in Metazoa (literal)
- Abstract
- Mitochondria are sub-cellular organelles that have a central role in energy production and
in other metabolic pathways of all eukaryotic respiring cells. In the last few years, with more and more
genomes being sequenced, a huge amount of data has been generated providing an unprecedented
opportunity to use the comparative analysis approach in studies of evolution and functional genomics with
the aim of shedding light on molecular mechanisms regulating mitochondrial biogenesis and metabolism.
In this context, the problem of the optimal extraction of representative datasets of genomic and proteomic
data assumes a crucial importance. Specialised resources for nuclear-encoded mitochondria-related
proteins already exist; however, no mitochondrial database is currently available with the same features
of MitoRes, which is an update of the MitoNuc database extensively modified in its structure, data sources
and graphical interface. It contains data on nuclear-encoded mitochondria-related products for any
metazoan species for which this type of data is available and also provides comprehensive sequence
datasets (gene, transcript and protein) as well as useful tools for their extraction and export.
MitoRes http://www2.ba.itb.cnr.it/MitoRes/ consolidates information from publicly external
sources and automatically annotates them into a relational database. Additionally, it also clusters proteins
on the basis of their sequence similarity and interconnects them with genomic data. The search engine and
sequence management tools allow the query/retrieval of the database content and the extraction and
export of sequences (gene, transcript, protein) and related sub-sequences (intron, exon, UTR, CDS, signal
peptide and gene flanking regions) ready to be used for in silico analysis.
The tool we describe here has been developed to support lab scientists and
bioinformaticians alike in the characterization of molecular features and evolution of mitochondrial
targeting sequences. The way it provides for the retrieval and extraction of sequences allows the user to
overcome the obstacles encountered in the integrative use of different bioinformatic resources and the
completeness of the sequence collection allows intra- and interspecies comparison at different biological
levels (gene, transcript and protein). (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi