3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]hep (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• 3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]hep (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bmc.2007.03.035, (literal)

Alternative label

• Loriga G, Ruiu S, Manca I, Murineddu G, Dessi C, Pani L, Pinna GA (2007)
  3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]hep
  in Bioorganic & medicinal chemistry (Print); ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Loriga G, Ruiu S, Manca I, Murineddu G, Dessi C, Pani L, Pinna GA (literal)

Pagina inizio

• 3748 (literal)

Pagina fine

• 3755 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• https://www.sciencedirect.com (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Bioorganic & medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-Istituto di Tecnologie Biomediche, Italy Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, via F. Muroni 23/A, I-07100 Sassari, Italy Neuroscienze PharmaNess S.c.a r.l., Technological Park of Sardinia ‘Polaris’ Loc. Piscinamanna, I-09010 Pula, Cagliari, Italy (literal)

Titolo

• 3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]hep (literal)

Abstract

• A series of analogues 2a-i related to 3-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-8-(1H-indol-2-ylmethyl)-3,8-diazabicyclo [3.2.1]octane (1) in which the 3,8-diazabicyclo[3.2.1]octane core was replaced by 3,6-diazabicyclo[3.1.1]heptane ring system has been synthesized and evaluated fortheir ability to inhibit DA reuptake into striatal nerve endings (synaptosomes). Biological data showed that compound 2a, the closest analogue of lead 1, possessed an increased reuptake inhibition activity over 1 (2a, K(i)=5.5 nM). Replacement of the indole ring with bioisosteric aromatic rings—benzothiophene (2b), benzofurane (2c), or indene (2d)--resulted, with the exception of 2d, in a double digit nanomolar activity. Changing the indenyl moiety of 2d with simplified aryl groups led to compounds 2e-h which displayed a similar or slightly decreased activity with respect to the ground term. Naphthalene derivative (2i) demonstrated a weaker activity than aromatic analogues (literal)

Editore

• ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS (Editore)

Prodotto di

• Drug design, drug delivery e valutazione preclinica di nuove entità chimiche. (ME.P06.020.001) (Modulo)

Autore CNR

• LUCA PANI (Persona)
• STEFANIA RUIU (Unità di personale interno)

Insieme di parole chiave

• Keywords of "3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]hep" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• STEFANIA RUIU (Unità di personale interno)
• LUCA PANI (Persona)

Prodotto

• Drug design, drug delivery e valutazione preclinica di nuove entità chimiche. (ME.P06.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bioorganic & medicinal chemistry (Rivista)

Editore di

• ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS (Editore)

Insieme di parole chiave di

• Keywords of "3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]hep" (Insieme di parole chiave)