Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity (Articolo in rivista)

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  • Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1186/1471-2105-6-S4-S20 (literal)
Alternative label
  • Milanesi, L; Petrillo, M; Sepe, L; Boccia, A; D'Agostino, N; Passamano, M; Di Nardo, S; Tasco, G; Casadio, R; Paolella, G (2005)
    Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity
    in BMC bioinformatics
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Milanesi, L; Petrillo, M; Sepe, L; Boccia, A; D'Agostino, N; Passamano, M; Di Nardo, S; Tasco, G; Casadio, R; Paolella, G (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 6 (literal)
Rivista
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  • 11 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • Consiglio Nazionale delle Ricerche (CNR); CILEA; CEINGE Biotecnol Avanzate; University of Naples Federico II; University of Bologna; Univ Molise (literal)
Titolo
  • Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity (literal)
Abstract
  • Background: Protein kinases are a well defined family of proteins, characterized by the presence of a common kinase catalytic domain and playing a significant role in many important cellular processes, such as proliferation, maintenance of cell shape, apoptosys. In many members of the family, additional non-kinase domains contribute further specialization, resulting in subcellular localization, protein binding and regulation of activity, among others. About 500 genes encode members of the kinase family in the human genome, and although many of them represent well known genes, a larger number of genes code for proteins of more recent identification, or for unknown proteins identified as kinase only after computational studies. (literal)
  • Results: A systematic in silico study performed on the human genome, led to the identification of 5 genes, on chromosome 1, 11, 13, 15 and 16 respectively, and 1 pseudogene on chromosome X; some of these genes are reported as kinases from NCBI but are absent in other databases, such as KinBase. Comparative analysis of 483 gene regions and subsequent computational analysis, aimed at identifying unannotated exons, indicates that a large number of kinase may code for alternately spliced forms or be incorrectly annotated. An InterProScan automated analysis was perfomed to study domain distribution and combination in the various families. At the same time, other structural features were also added to the annotation process, including the putative presence of transmembrane alpha helices, and the cystein propensity to participate into a disulfide bridge. (literal)
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