Physical and transcript map of the hereditary prostate cancer region at Xq27 (Articolo in rivista)

Type
Label
  • Physical and transcript map of the hereditary prostate cancer region at Xq27 (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1006/geno.2001.6681 (literal)
Alternative label
  • Stephan, DA; Howell, GR; Teslovich, TM; Coffey, AJ; Smith, L; Bailey-Wilson, JE; Malechek, L; Gildea, D; Smith, JR; Gillanders, EM; Schleutker, J; Hu, P; Steingruber, HE; Dhami, P; Robbins, CM; Makalowska, I; Carpten, JD; Sood, R; Mumm, S; Reinbold, R; Bonner, TI; Baffoe-Bonnie, A; Bubendorf, L; Heiskanen, M; Kallioneimi, OP; Baxevanis, AD; Joseph, SS; Zucchi, I; Burk, RD; Isaacs, W; Ross, MT; Trent, JM (2002)
    Physical and transcript map of the hereditary prostate cancer region at Xq27
    in Genomics (S. Diego Calif.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Stephan, DA; Howell, GR; Teslovich, TM; Coffey, AJ; Smith, L; Bailey-Wilson, JE; Malechek, L; Gildea, D; Smith, JR; Gillanders, EM; Schleutker, J; Hu, P; Steingruber, HE; Dhami, P; Robbins, CM; Makalowska, I; Carpten, JD; Sood, R; Mumm, S; Reinbold, R; Bonner, TI; Baffoe-Bonnie, A; Bubendorf, L; Heiskanen, M; Kallioneimi, OP; Baxevanis, AD; Joseph, SS; Zucchi, I; Burk, RD; Isaacs, W; Ross, MT; Trent, JM (literal)
Pagina inizio
  • 41 (literal)
Pagina fine
  • 50 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 79 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • National Institutes of Health (NIH) - USA; Wellcome Trust Sanger Institute; Albert Einstein College of Medicine; National Institutes of Health (NIH) - USA; Vanderbilt University; University of Tampere; National Institutes of Health (NIH) - USA; Consiglio Nazionale delle Ricerche (CNR); National Institute of Mental Health (NIMH); Fox Chase Cancer Center; Johns Hopkins University (literal)
Titolo
  • Physical and transcript map of the hereditary prostate cancer region at Xq27 (literal)
Abstract
  • We have recently mapped a locus for hereditary prostate cancer (termed HPCX) to the long arm of the X chromosome (Xq25-q27) through a genome-wide linkage study. Here we report the construction of an similar to 9-Mb sequence-ready bacterial clone contig map of Xq26.3-q27.3. The contig was constructed by screening BAC/PAC libraries with markers spaced at similar to 85-kb intervals. We identified overlapping clones by end-sequencing framework clones to generate 407 new sequence-tagged sites, followed by PCR verification of overlaps. Contig assembly was based on clone restriction fingerprinting and the landmark information. We identified a minimal overlap contig for genomic sequencing, which has yielded 7.7 Mb of finished sequence and 1.5 Mb of draft sequence. The transcriptional mapping effort localized 57 known and predicted genes by database searching, STS content mapping, and sequencing, followed by sequence annotation. These transcriptional units represent candidate genes for HPCX and multiple other hereditary diseases at Xq26.3-q27.3. (literal)
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