http://www.cnr.it/ontology/cnr/individuo/prodotto/ID54158
Fractionation and characterization of a conjugate between a polymeric drug-carrier and the anti-tumor drug Camptothecin (Articolo in rivista)
- Type
- Label
- Fractionation and characterization of a conjugate between a polymeric drug-carrier and the anti-tumor drug Camptothecin (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Mendichi R. 1, Rizzo V. 2, Gigli M. 3, Giacometti Schieroni A. 4 (2002)
Fractionation and characterization of a conjugate between a polymeric drug-carrier and the anti-tumor drug Camptothecin
in Bioconjugate chemistry
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Mendichi R. 1, Rizzo V. 2, Gigli M. 3, Giacometti Schieroni A. 4 (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1, 4 per lo Studio delle Macromolecole (CNR), Via E. Bassini 15, 20133 Milan, Italy.
2, 3 Pharmacia, Viale Pasteur 10, 20014 Nerviano (MI), Italy. (literal)
- Titolo
- Fractionation and characterization of a conjugate between a polymeric drug-carrier and the anti-tumor drug Camptothecin (literal)
- Abstract
- A conjugate between the antitumor drug camptothecin and the polymeric
drug-carrier Poly[N-(2-hydroxypropyl)methacrylamide)] was synthesized and
fractionated. The conjugate sampleswere characterized with a multi-
detector SEC system using three on-line detectors: a multi-angle light
scattering, a viscometer and a refractometer. The used mobile phase
(DMF+0.01M LiBr+0.05M CH3COOH) derives from previous experience with
similar conjugates. Narrow molar mass distribution fractions of the
conjugate obtained by means of a semi-preparative LC system were used to
derive the coefficients of the Mark-Houwink-Sakurada relationship and to
check the universal calibration of the SEC system. This study has
demonstrated that the conjugate elutes according to the hydrodynamic
volume. Thus a conventional SEC method that uses only an on-line
refractometer detector, commercially available narrow standards and the
universal calibration is adequate to the characterization of the molar
mass distribution. Also the size and the conformation of the conjugate
were studied by means of the gyration radius-molar mass power law. (literal)
- Prodotto di
- Autore CNR
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