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NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function analysis of viscotoxins (Articolo in rivista)
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- NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function analysis of viscotoxins (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1021/bi034762t (literal)
- Alternative label
Romagnoli S , Fogolari F , Catalano M , Zetta L, Schaller G, Urech K, Giannattasio M, Ragona L, Molinari H (2003)
NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function analysis of viscotoxins
in Biochemistry (Easton)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Romagnoli S , Fogolari F , Catalano M , Zetta L, Schaller G, Urech K, Giannattasio M, Ragona L, Molinari H (literal)
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- Impact factor 2002: 4.06 (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1)Dipartimento Scientifico e Tecnologico, UniVersita ` degli Studi di Verona, Strada le Grazie 15, 37134 Verona, Italy,
2)Laboratorio NMR, ISMAC-CNR, Via Bassini 15, 20133 Milano, Italy,
3)Verein fur Krebsforschung, Hiscia Institute,4144 Arlesheim, Switzerland, 4)Dipartimento di Arboricoltura, Botanica e Patologia Vegetale, Facolta` di Agraria,UniVersita` di Napoli, Portici, 80100 Napoli, Italy (literal)
- Titolo
- NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function analysis of viscotoxins (literal)
- Abstract
- The high resolution three-dimensional structure of the newly discovered plant viscotoxin C1, from the Asiatic Viscum album ssp. Coloratum ohwi, has been determined in solution by (1)H NMR spectroscopy at pH 3.6 and 285 K. The viscotoxin C1-fold, consisting of a helix-turn-helix motif and a short stretch of an antiparralel beta-sheet is very similar to that found for the highly similar viscotoxins A2 and A3 and for other related thionins. Different functional properties of members of the thionin family are discussed here in light of the structural and electrostatic properties. Among the very homologous family of alpha- and beta-thionins, known for their antimicrobial activity, the viscotoxin subfamily differs from the other members because of its high toxicity against tumoral cells. Key residues for the modulation of viscotoxin cytotoxicity have been identified on the basis of sequence and structural alignment. (literal)
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