DNA supercoiling in apoptotic chromatin (Articolo in rivista)

Type
Label
  • DNA supercoiling in apoptotic chromatin (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbrc.2003.08.036 (literal)
Alternative label
  • D'Arrigo C., Barboro P., Mormino M., Coradeghini R., Parodi S., Patrone E., Balbi C. (2003)
    DNA supercoiling in apoptotic chromatin
    in Biochemical and biophysical research communications (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • D'Arrigo C., Barboro P., Mormino M., Coradeghini R., Parodi S., Patrone E., Balbi C. (literal)
Pagina inizio
  • 540 (literal)
Pagina fine
  • 546 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://ac.els-cdn.com/S0006291X03016292/1-s2.0-S0006291X03016292-main.pdf?_tid=788d0894-46ff-11e3-bf04-00000aab0f02&acdnat=1383755060_d7b988335bcc272ac6082a84aed209a8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 309 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • D'Arrigo C., Mormino M., Patrone E. Ist Studio Macromol, Sez Genova, I-16146 Genoa, Italy Barboro P., Coradeghini R., Parodi S., Balbi C. Ist Nazl Ric Canc, I-16132 Genoa, Italy Coradeghini R., Parodi S. Univ Genoa, Dipartimento Oncol Biol & Genet. (literal)
Titolo
  • DNA supercoiling in apoptotic chromatin (literal)
Abstract
  • In a previous paper, we have reported that in rat thymocyte apoptosis chromatin undergoes a specific structural change as well as an appreciable increase in the unacetylated forms of histones H3 and H4. Here, we show that H3 and H4 deacetylation bears no relation to chromatin condensation, and present new ultrastructural and topological observations that largely clarify the organization of the condensed state. The texture of the latter corresponds to a closely woven network of negatively supercoiled 11 rim fibers, as shown by both ultrastructural observations and relaxation experiments using ethidium bromide. Circularly closed chromatin loops undergoing apoptotic condensation, clearly showing nucleosome compact dimers or higher oligomers, as well as long stretches of supercoiled DNA, have also been detected. All of these modifications are strongly reminiscent of the alterations induced in nucleosome bearing plasmids by the chromatin remodeling factors SWI/SNF and RSC. (literal)
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