http://www.cnr.it/ontology/cnr/individuo/prodotto/ID54010
A cyclodextrin-based nanossembly with bimodal photodynamic action (Articolo in rivista)
- Type
- Label
- A cyclodextrin-based nanossembly with bimodal photodynamic action (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/chem.201101635 (literal)
- Alternative label
N. Kandoth; E. Vittorino; M.T. Sciortino; T. Parisi; I. Colao; A. Mazzaglia; S. Sortino (2012)
A cyclodextrin-based nanossembly with bimodal photodynamic action
in Chemistry (Weinh., Print); Wiley-VCH Verlag Gmbh, Weinheim (Germania)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- N. Kandoth; E. Vittorino; M.T. Sciortino; T. Parisi; I. Colao; A. Mazzaglia; S. Sortino (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- Scopu (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Noufal Kanfoth, Elisa Vittorino, Salvatore Sortino: Department of Drug Sciences, Catania, Italy; Maria Teresa Sciortino, Tiziana Parisi, Ivana Colao: Dipartimento di Scienze della Vita, Sezione di Scienze Microbiologiche Genetiche Molecolari, Università di Messina, Messina, Italy; Antonino Mazzaglia: Istituto per lo Studio dei Materiali Nanostrutturati, ISMN-CNR (literal)
- Titolo
- A cyclodextrin-based nanossembly with bimodal photodynamic action (literal)
- Abstract
- We have developed a supramolecular
nanoassembly capable of inducing
remarkable levels of cancer cell
mortality through a bimodal action
based on the simultaneous photogeneration
of nitric oxide (NO) and singlet
oxygen (1O2). This was achieved
through the appropriate incorporation
of an anionic porphyrin (as 1O2 photosensitizer)
and of a tailored NO photodonor
in different compartments of
biocompatible nanoparticles based on
cationic amphiphilic cyclodextrins. The
combination of steady-state and timeresolved
spectroscopic techniques
showed the absence of significant intraand
interchromophoric interaction between
the two photoactive centers embedded
in the nanoparticles, with consequent
preservation of their photodynamic
properties. Photodelivery of NO
and 1O2 from the nanoassembly on
visible light excitation was unambiguously
demonstrated by direct and realtime
monitoring of these transient species
through amperometric and timeresolved
infrared luminescence measurements,
respectively. The typical red
fluorescence of the porphyrin units was
essentially unaffected in the bichromophoric
nanoassembly, allowing its localization
in living cells. The convergence
of the dual therapeutic action and the
imaging capacities in one single structure
makes this supramolecular architecture
an appealing, multifunctional
candidate for applications in biomedical
research. (literal)
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