http://www.cnr.it/ontology/cnr/individuo/prodotto/ID53946
A novel route in bone tissue engineering: magnetic biomimetic scaffolds (Articolo in rivista)
- Type
- Label
- A novel route in bone tissue engineering: magnetic biomimetic scaffolds (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.actbio.2009.09.017 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- N. Bock; A. Riminucci; C. Dionigi; A. Russo; A Tampieri; E. Landi; V.A. Goranov; M. Marcacci; V. Dediu (literal)
- Pagina inizio
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://ac.els-cdn.com/S1742706109004127/1-s2.0-S1742706109004127-main.pdf?_tid=80f562f6ab52919b47dffae25c25433c&acdnat=1335515808_a1a064674bc679e8927b7366b41b657f (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Titolo
- A novel route in bone tissue engineering: magnetic biomimetic scaffolds (literal)
- Abstract
- In recent years, interest in tissue engineering and its solutions has increased considerably. In particular,
scaffolds have become fundamental tools in bone graft substitution and are used in combination with a
variety of bio-agents. However, a long-standing problem in the use of these conventional scaffolds lies in
the impossibility of re-loading the scaffold with the bio-agents after implantation. This work introduces
the magnetic scaffold as a conceptually new solution. The magnetic scaffold is able, via magnetic driving,
to attract and take up in vivo growth factors, stem cells or other bio-agents bound to magnetic particles.
The authors succeeded in developing a simple and inexpensive technique able to transform standard
commercial scaffolds made of hydroxyapatite and collagen in magnetic scaffolds. This innovative process
involves dip-coating of the scaffolds in aqueous ferrofluids containing iron oxide nanoparticles coated
with various biopolymers. After dip-coating, the nanoparticles are integrated into the structure of the
scaffolds, providing the latter with magnetization values as high as 15 emu g?1 at 10 kOe. These values
are suitable for generating magnetic gradients, enabling magnetic guiding in the vicinity and inside
the scaffold. The magnetic scaffolds do not suffer from any structural damage during the process, maintaining
their specific porosity and shape. Moreover, they do not release magnetic particles under a constant
flow of simulated body fluids over a period of 8 days. Finally, preliminary studies indicate the ability
of the magnetic scaffolds to support adhesion and proliferation of human bone marrow stem cells in vitro.
Hence, this new type of scaffold is a valuable candidate for tissue engineering applications, featuring a
novel magnetic guiding option. (literal)
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