Capacitance DNA bio-chips improved by new probe immobilization strategies (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Capacitance DNA bio-chips improved by new probe immobilization strategies (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.mejo.2010.01.007 (literal)

Alternative label

• S. Carrara (1), A. Cavallini (1), J. Leblebici (1), G.de Micheli (1), V. Bhalla (2), F. Valle (2), B. Samorì (2), L. Benini (3), B. Riccò (3), I. Vikholm-Lundin (4), T. Munter (4) (2010)
  Capacitance DNA bio-chips improved by new probe immobilization strategies
  in Microelectronics
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• S. Carrara (1), A. Cavallini (1), J. Leblebici (1), G.de Micheli (1), V. Bhalla (2), F. Valle (2), B. Samorì (2), L. Benini (3), B. Riccò (3), I. Vikholm-Lundin (4), T. Munter (4) (literal)

Pagina inizio

• 711 (literal)

Pagina fine

• 714 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 41 (literal)

Rivista

• Microelectronics (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (1) EPFL, Swiss Federal Institute of Technology, Lausanne CH-1015 Lausanne (CH), Switzerland (2) Biochemistry Department, Bologna University (IT), Bologna (3) D.E.I.S. Department, Bologna University (IT), Bologna (4) Technical Research Centre of Finland (VTT), Tampere, Finland (literal)

Titolo

• Capacitance DNA bio-chips improved by new probe immobilization strategies (literal)

Abstract

• Label-free DNA detection plays a crucial role in developing point-of-care biochips. Capacitance detection is a promising technology for label-free detection. However, data published in literature often show evident time drift, large standard deviation, scattered data points, and poor reproducibility. To address these problems, mercapto-hexanol or similar alkanethiols are usually considered as blocking agents. The aim of the present paper is to investigate new blocking agents to further improve DNA probe surfaces. Data from AFM, SPR, florescence microscopy, and capacitance measurements are used to investigate new lipoate and ethylene-glycol molecules. The new surfaces offer further improvements in terms of diminished detection errors. Film structures are investigated at the nano-scale to justify the detection improvements in terms of probe surface quality. This study demonstrates the superiority of lipoate and ethylene-glycol molecules as blocking candidates when immobilizing molecular probes onto spot surfaces in label-free DNA biochip. (literal)

Prodotto di

• Nanotecnologie di materiali multifunzionali e sistemi biologici (PM.P05.010.001) (Modulo)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)

Autore CNR

• FRANCESCO VALLE (Unità di personale interno)

Incoming links:

Prodotto

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Nanotecnologie di materiali multifunzionali e sistemi biologici (PM.P05.010.001) (Modulo)

Autore CNR di

• FRANCESCO VALLE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Microelectronics (Rivista)