Effects of Fe3O4 magnetic nanoparticles on lysozyme amyloid aggregation (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Effects of Fe3O4 magnetic nanoparticles on lysozyme amyloid aggregation (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1088/0957-4484/21/6/065103 (literal)

Alternative label

• A. Bellova (1), E. Bystrenova (2), M. Koneracka (1), F. Valle (2), N. Tomasovicova (1), M. Timko (1), J. Bagelova (1), F. Biscarini (2), Z. Gazova (1) (2010)
  Effects of Fe3O4 magnetic nanoparticles on lysozyme amyloid aggregation
  in Nanotechnology (Bristol. Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• A. Bellova (1), E. Bystrenova (2), M. Koneracka (1), F. Valle (2), N. Tomasovicova (1), M. Timko (1), J. Bagelova (1), F. Biscarini (2), Z. Gazova (1) (literal)

Pagina inizio

• 65103 (literal)

Pagina fine

• 65108 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• Nanotechnology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (1) Department of Biophysics, Department of Magnetism, Institute of Experimental Physics, Slovak Academy of Science, Watsonova 47, 04001 Kosice, Slovakia (2) CNR--Instituto per lo Studio dei Materiali Nanostrutturati, via Gobetti 101, I-40129 Bologna, Italy (literal)

Titolo

• Effects of Fe3O4 magnetic nanoparticles on lysozyme amyloid aggregation (literal)

Abstract

• Peptide amyloid aggregation is a hallmark of several human pathologies termed amyloid diseases. We have investigated the effect of electrostatically stabilized magnetic nanoparticles of Fe3O4 on the amyloid aggregation of lysozyme, as a prototypical amyloidogenic protein. Thioflavin T fluorescence assay and atomic force microscopy were used for monitoring the inhibiting and disassembly activity of magnetic nanoparticles of Fe3O4. We have found that magnetic Fe3O4 nanoparticles are able to interact with lysozyme amyloids in vitro leading to a reduction of the amyloid aggregates, thus promoting depolymerization; the studied nanoparticles also inhibit lysozyme amyloid aggregation. The ability to inhibit lysozyme amyloid formation and promote lysozyme amyloid disassembly exhibit concentration-dependent characteristics with IC50 = 0.65 mg ml-1 and DC50 = 0.16 mg ml-1 indicating that nanoparticles interfere with lysozyme aggregation already at stoichiometric concentrations. These features make Fe3O4 nanoparticles of potential interest as therapeutic agents against amyloid diseases and their non-risk exploitation nanodiagnostics. (literal)

Prodotto di

• Nanotecnologie di materiali multifunzionali e sistemi biologici (PM.P05.010.001) (Modulo)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)

Autore CNR

• FABIO BISCARINI (Unità di personale interno)
• EVA BYSTRENOVA (Persona)
• FRANCESCO VALLE (Persona)

Incoming links:

Prodotto

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Nanotecnologie di materiali multifunzionali e sistemi biologici (PM.P05.010.001) (Modulo)

Autore CNR di

• FRANCESCO VALLE (Persona)
• FABIO BISCARINI (Unità di personale interno)
• EVA BYSTRENOVA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nanotechnology (Rivista)